We used voxel-based morphometry and resting-state functional magnetic resonance imaging (rs-fMRI) to investigate whether the regulatory mode orientation of assessment (the tendency of each individual to self-regulate by critically evaluating alternatives) interacts with neural systems underlying risk-taking. Across a sample of 112 participants, propensity for risk-taking (measured using the Wheel of Fortune task) was negatively correlated with assessment orientation, such that a greater tendency to critically evaluate alternatives was associated with a lower tendency for risk-taking. VBM revealed a negative correlation between assessment orientation and right inferior parietal lobe (RIPL) gray matter volume. Resting-state functional connectivity (rs-FC) between this same RIPL region and the left inferior frontal gyrus (LIFG) was positively correlated with assessment orientation in an independent sample of 41 participants. Most importantly, based on the rs-FC results, a mediation analysis indicated that assessment orientation played a completely mediating role in the relation between the functional connectivity of RIPL-LIFG and risk-taking. These results suggest that assessment orientation may affect risk-taking via the RIPL and its connectivity with LIFG. On the whole, the present study yields the insights into how the assessment dimension of regulatory mode affects risk-taking, and provides a novel account of the neural substrate of this relationship.

中文翻译：

---

监管模式的评估维度介导了额顶连接与冒险之间的关系：基于体素的形态学和功能连接分析的证据。

我们使用了基于体素的形态计量学和静止状态功能磁共振成像（rs-fMRI），研究了评估的调节模式方向（每个人通过严格评估替代方案进行自我调节的趋势）是否与潜在的神经系统相互作用。服用。在112名参与者的样本中，冒险的倾向（使用“命运之轮”任务衡量）与评估方向呈负相关，因此，批判性评估替代方案的更大倾向与更低的冒险倾向相关。VBM显示评估方向与右下顶叶（RIPL）灰质体积之间呈负相关。在41名参与者的独立样本中，同一RIPL区域与左下额回（LIFG）之间的静止状态功能连接（rs-FC）与评估方向呈正相关。最重要的是，基于rs-FC的结果，调解分析表明，评估方向在RIPL-LIFG的功能连接性与承担风险之间的关系中起着完全调解的作用。这些结果表明，评估导向可能会通过RIPL及其与LIFG的关联性影响风险承担。总体而言，本研究对监管模式的评估维度如何影响冒险产生了见解，并为这种关系的神经基础提供了新的解释。根据rs-FC的结果，调解分析表明，评估导向在RIPL-LIFG的功能连接性与冒险精神之间的关系中起着完全调解的作用。这些结果表明，评估导向可能会通过RIPL及其与LIFG的关联性影响风险承担。总体而言，本研究对监管模式的评估维度如何影响冒险产生了见解，并为这种关系的神经基础提供了新的解释。根据rs-FC的结果，调解分析表明，评估导向在RIPL-LIFG的功能连接性与冒险精神之间的关系中起着完全调解的作用。这些结果表明，评估导向可能会通过RIPL及其与LIFG的关联性影响风险承担。总体而言，本研究对监管模式的评估维度如何影响冒险产生了见解，并为这种关系的神经基础提供了新的解释。