The aim of the study was to comparatively assess delafloxacin and levofloxacin activities against 96 anaerobic and some microaerophilic isolates. Delafloxacin minimal inhibitory concentrations (MICs) were strikingly lower than those of levofloxacin. Delafloxacin MIC₉₀ against clostridia, other Gram-positive rods, anaerobic/microaerophilic cocci and Gram-negative rods were 0.75, 0.032, 0.38 and 0.5 μg/mL, respectively. The highest (≥4 μg/mL) MICs of the newer fluoroquinolone were found in only 4.2% of isolates versus 46.9% by levofloxacin. The present results and the potency in acidic conditions showed delafloxacin advantages over levofloxacin in terms of usefulness for treatment of mixed anaerobic-aerobic infections and activity against Clostridioides (Clostridium) difficile.

该研究的目的是比较地拉氟沙星和左氧氟沙星对96种厌氧菌和一些微需氧菌的活性。德拉福沙星的最低抑菌浓度（MICs）明显低于左氧氟沙星。对抗梭菌，其他革兰氏阳性棒，厌氧/微需氧球菌和革兰氏阴性棒的德拉福沙星MIC _90分别为0.75、0.032、0.38和0.5μg/ mL。新型氟喹诺酮类药物的最高MIC（≥4μg/ mL）仅在4.2％的分离物中被发现，而左氧氟沙星在46.9％的分离物中被发现。本发明的结果和在酸性条件下的效力显示出地氟沙星相对于左氧氟沙星的优势在于可用于治疗厌氧-需氧混合感染以及对艰难梭菌（梭菌）的活性。