Sialic acid-binding immunoglobulin-type lectins (Siglecs) are expressed on the majority of white blood cells of the immune system and play critical roles in immune cell signaling. Through recognition of sialic acid-containing glycans as ligands, they help the immune system distinguish between self and nonself. Because of their restricted cell type expression and roles as checkpoints in immune cell responses in human diseases such as cancer, asthma, allergy, neurodegeneration, and autoimmune diseases they have gained attention as targets for therapeutic interventions. In this review we describe the Siglec family, its roles in regulation of immune cell signaling, current efforts to define its roles in disease processes, and approaches to target Siglecs for treatment of human disease.

中文翻译：

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Siglecs 作为疾病中的免疫细胞检查点。

唾液酸结合免疫球蛋白型凝集素 (Siglecs) 在免疫系统的大多数白细胞上表达，并在免疫细胞信号传导中起关键作用。通过将含唾液酸的聚糖识别为配体，它们帮助免疫系统区分自身和非自身。由于它们在癌症、哮喘、过敏、神经退行性疾病和自身免疫性疾病等人类疾病中作为免疫细胞反应检查点的受限细胞类型表达和作用，它们作为治疗干预的靶点而受到关注。在这篇综述中，我们描述了 Siglec 家族、它在调节免疫细胞信号传导中的作用、目前定义其在疾病过程中的作用的努力，以及靶向 Siglecs 治疗人类疾病的方法。