During the first trimester of pregnancy the decidua is comprised of decidual stromal cells (DSC), invading fetal trophoblast cells and maternal leukocytes, including decidual natural killer (dNK) cells and macrophages. dNK cells are distinct from peripheral blood NK cells and have a role in regulating trophoblast invasion and spiral artery remodelling. The unique phenotype of dNK cells results from the decidual environment in which they reside, however the interaction and influence of other cells in the decidua on dNK phenotype is unknown. We isolated first trimester DSC and decidual macrophages and investigated the effect that DSC and decidual macrophage secreted factors have on CD56+ decidual lymphocyte receptor expression and cytokine secretion (including dNK cells). We report that DSC secreted factors induce the secretion of the cytokines IL-8 and IL-6 from first trimester CD56+ cells. However, neither DSC nor decidual macrophage secreted factors changed CD56+ cell receptor expression. These results suggest that secreted factors from DSC influence CD56+ decidual lymphocytes during the first trimester of pregnancy and therefore may play a role in regulating the unique phenotype and function of dNK cells during placentation.

中文翻译：

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蜕膜CD56 +淋巴细胞的表型受妊娠中期蜕膜蜕膜细胞分泌因子的影响，而不受巨噬细胞的影响。

在妊娠的前三个月，蜕膜由蜕膜基质细胞（DSC），侵袭性胎儿滋养层细胞和母体白细胞组成，包括蜕膜自然杀伤（dNK）细胞和巨噬细胞。dNK细胞不同于外周血NK细胞，并在调节滋养细胞侵袭和螺旋动脉重塑中发挥作用。dNK细胞的独特表型是由它们所处的蜕膜环境产生的，但是蜕膜中其他细胞对dNK表型的相互作用和影响尚不清楚。我们分离了早孕期DSC和蜕膜巨噬细胞，并研究了DSC和蜕膜巨噬细胞分泌因子对CD56 +蜕膜淋巴细胞受体表达和细胞因子分泌（包括dNK细胞）的影响。我们报告说，DSC分泌的因子诱导从孕早期CD56 +细胞分泌细胞因子IL-8和IL-6。但是，DSC和蜕膜巨噬细胞分泌因子均未改变CD56 +细胞受体的表达。这些结果表明，DSC的分泌因子在怀孕的前三个月影响CD56 +蜕膜淋巴细胞，因此可能在胎盘形成过程中调节dNK细胞的独特表型和功能。