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An Extended Twin-Pedigree Study of Different Classes of Voluntary Exercise Behavior.
Behavior Genetics ( IF 2.6 ) Pub Date : 2020-01-23 , DOI: 10.1007/s10519-019-09990-7
Matthijs D van der Zee 1 , Q Helmer 1 , D I Boomsma 1 , C V Dolan 1 , E J C de Geus 1
Affiliation  

We investigated the familial clustering of different classes of voluntary regular exercise behavior in extended twin-family pedigrees. In contrast to the earlier work based on twin data only, this allowed us to estimate the contributions of shared household effects (C), additive (A), and non-additive (D) genetic effects on voluntary exercise behavior. To test whether shared household effects were inflated by assortative mating we examined the causes of spousal resemblance. For adolescent and adult participants (aged 16 to 65) in the Netherlands Twin Register we constructed 19,543 pedigrees which specified all relations among nuclear family members and larger families in the register (N = 50,690 individuals). Data were available on total weekly MET minutes spent on leisure time exercise, and on total weekly MET minutes spent on exercise activities in team-based, solitary, competitive, non-competitive, externally paced and internally paced exercise. We analyzed the data in the Mendel software package (Lange et al. in Bioinformatics 29(12):1568-1570, 2013) under multiple definitions of household sharing and used data from spouses of twins to test phenotypic assortment, social homogamy, and marital interaction as potential sources of spousal resemblance. Results confirmed the influence of genetic factors on the total volume of weekly exercise behavior throughout the life span. Broad sense heritability ranged from 34 to 41% (19-26% A, 12-21% D), and did not depend on the definition for household sharing. Engaging in team-based, competitive, externally paced activities (e.g., soccer) was ~ 13% more heritable than engaging in non-competitive, solitary activities (e.g., jogging). Having shared a household as siblings explained 4-8% of the variance in adult exercise behavior, whereas sharing a household by spouses yielded higher C estimates (20-24%), as it incorporates spousal resemblance. Spousal resemblance was explained by both social homogamy and marital interaction, with little evidence for phenotypic assortment. We conclude that both the amount of voluntary exercise behavior and the preference for specific classes of exercise activities in adults is explained by additive and non-additive genetic factors and unique environmental influences that include correlated exercise behavior of spouses.

中文翻译:

不同类别的自愿运动行为的扩展双谱系研究。

我们调查了双亲家庭谱系中不同类别的自愿定期锻炼行为的家族聚类。与仅基于双胞胎数据的早期工作相比,这使我们能够估计共有的家庭效应(C),加性(A)和非加性(D)遗传效应对自愿锻炼行为的贡献。为了检验是否因配偶而加剧了共同的家庭影响,我们研究了配偶相似的原因。对于荷兰双胞胎登记册中的青少年和成年参与者(16至65岁),我们构建了19,543个谱系,其中指定了登记册中核家庭成员和较大家庭(N = 50,690个人)之间的所有关系。可获得有关休闲运动每周花费的MET分钟的数据,以及在基于团队的,单独的,有竞争性的,无竞争性的,有外部节奏的和有内部节奏的运动中,每周在运动活动上花费的MET总分钟数。我们分析了Mendel软件包中的数据(Lange et al。in Bioinformatics 29(12):1568-1570,2013)在家庭共享的多种定义下的数据,并使用了双胞胎配偶的数据来测试表型分类,社会同性和婚姻状况。互动是夫妻相似的潜在来源。结果证实了遗传因素对整个生命周期每周锻炼行为总量的影响。广义遗传率范围为34%至41%(A为19-26%,D为12-21%),并且不取决于家庭共享的定义。参与基于团队的,具有竞争性的,由外部安排的活动(例如,足球)比进行非竞争性的单独活动(例如慢跑)的可遗传性高出13%。与兄弟姐妹同住一个家庭可以解释成人运动行为差异的4-8%,而与配偶同住一个家庭可以得出较高的C估计值(20-24%),因为它与配偶相似。社会同性和婚姻互动都可以说明配偶相似之处,但没有表型分类的证据。我们得出的结论是,成年人的自愿运动行为和对特定类别运动活动的偏好都由加性和非加性遗传因素以及包括相关配偶的运动行为在内的独特环境影响来解释。与兄弟姐妹同住一个家庭可以解释成人运动行为差异的4-8%,而与配偶同住一个家庭可以得出较高的C估计值(20-24%),因为它与配偶相似。社会同性和婚姻互动都可以说明配偶相似之处,但没有表型分类的证据。我们得出的结论是,成年人的自愿运动行为和对特定类别运动活动的偏好都由加性和非加性遗传因素以及包括相关配偶的运动行为在内的独特环境影响来解释。与兄弟姐妹同住一个家庭可以解释成人运动行为差异的4-8%,而与配偶同住一个家庭可以得出较高的C估计值(20-24%),因为它与配偶相似。社会同性和婚姻互动都可以说明配偶相似之处,但没有表型分类的证据。我们得出的结论是,成年人的自愿运动行为和对特定类别运动活动的偏好都由加性和非加性遗传因素以及包括相关配偶的运动行为在内的独特环境影响来解释。几乎没有表型分类的证据。我们得出的结论是,成年人的自愿运动行为的数量和对特定类别运动活动的偏好都由加性和非加性遗传因素以及包括相关配偶的运动行为在内的独特环境影响来解释。几乎没有表型分类的证据。我们得出的结论是,成年人的自愿运动行为和对特定类别运动活动的偏好都由加性和非加性遗传因素以及包括相关配偶的运动行为在内的独特环境影响来解释。
更新日期:2020-04-20
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