The GABA response switch from excitatory to inhibitory is a key event in neuronal maturation that depends on the regulated expression of chloride transporters NKCC1 and KCC2. In this issue, Lee et al. (2020. J. Cell. Biol.https://doi.org/10.1083/jcb.201903033) describe how degradation of NKCC1 by proteasomes immobilized at the axon initial segment (AIS) by the Ecm29 adaptor contributes to this regulation, driving the GABA switch and the positional maturation of the AIS.

中文翻译：

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GABA 输入，垃圾输出：AIS 蛋白酶体调节发育 GABA 开关

GABA 反应从兴奋性转变为抑制性是神经元成熟的关键事件，取决于氯离子转运蛋白 NKCC1 和 KCC2 的表达调节。在本期中，Lee 等人。(2020. J. Cell. Biol.https://doi.org/10.1083/jcb.201903033) 描述了 Ecm29 适配器固定在轴突初始段 (AIS) 的蛋白酶体对 NKCC1 的降解如何促进这种调节，从而驱动GABA 开关和 AIS 的位置成熟。