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Incorporation in Lipid Microparticles of Acid Red 87, a Colourant Used in Tattoo Inks: Effect on Photodegradation Under Simulated Sunlight and Laser Radiation
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2020-05-07 , DOI: 10.1111/php.13258 Santo Scalia 1 , Annachiara Dozzo 2 , Sofia Magli 1 , Giuseppe Scarcella 3
Photochemistry and Photobiology ( IF 2.6 ) Pub Date : 2020-05-07 , DOI: 10.1111/php.13258 Santo Scalia 1 , Annachiara Dozzo 2 , Sofia Magli 1 , Giuseppe Scarcella 3
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Tattoo colorants decompose under solar radiation and when exposed to laser light for their removal, leading to the accumulation in the dermis of toxic products. Aim of this study was to develop lipid microparticles (LMs) loaded with the colorant, Acid Red 87 (C.I. 45380) used in tattoo inks, and to investigate the effect of this system on the photostability of the colorant under simulated sunlight or laser irradiation. LMs loaded with C.I. 45380 were prepared by melt emulsification using tristearin and phosphatidylcholine as excipients. They were characterized by optical microscopy, laser diffraction, X‐ray diffraction and release studies. Free C.I. 45380 and the colorant‐loaded LMs were irradiated with a solar simulator or a Q‐switched laser. Irradiation with a solar simulator demonstrated that photodecomposition of C.I. 45380 was markedly reduced by incorporation of the dye in the LMs, from 20.5 ± 4.6% to 1.3 ± 1.8%. Conversely, the laser‐induced degradation of the colorant (30.1 ± 6.6%) was not significantly influenced by encapsulation in the LMs (the encapsulated C.I. 45380 loss was 27.4 ± 5.5%). Incorporation of C.I. 45380 in lipid microparticles enhances the photostability under sunlight of tattoo inks containing this colorant, without affecting its laser‐induced degradation and hence laser removal efficiency.
中文翻译：
酸性红 87 脂质微粒的掺入，一种用于纹身墨水的着色剂：在模拟阳光和激光辐射下对光降解的影响
纹身着色剂在太阳辐射和激光照射下会分解，导致有毒产品在真皮中积聚。本研究的目的是开发载有纹身油墨中使用的着色剂酸性红 87 (CI 45380) 的脂质微粒 (LM)，并研究该系统在模拟阳光或激光照射下对着色剂光稳定性的影响。使用三硬脂酸和磷脂酰胆碱作为赋形剂，通过熔融乳化制备负载 CI 45380 的 LM。它们通过光学显微镜、激光衍射、X 射线衍射和释放研究进行表征。用太阳模拟器或 Q 开关激光器照射游离 CI 45380 和加载了着色剂的 LM。用太阳模拟器辐照证明 CI 的光分解 通过在 LMs 中加入染料，45380 显着减少，从 20.5 ± 4.6% 到 1.3 ± 1.8%。相反，激光诱导的着色剂降解 (30.1 ± 6.6%) 不受 LM 封装的显着影响（封装的 CI 45380 损失为 27.4 ± 5.5%）。在脂质微粒中加入 CI 45380 可增强含有这种着色剂的纹身墨水在阳光下的光稳定性，而不影响其激光诱导降解，从而影响激光去除效率。
更新日期：2020-05-07
中文翻译：
酸性红 87 脂质微粒的掺入，一种用于纹身墨水的着色剂：在模拟阳光和激光辐射下对光降解的影响
纹身着色剂在太阳辐射和激光照射下会分解，导致有毒产品在真皮中积聚。本研究的目的是开发载有纹身油墨中使用的着色剂酸性红 87 (CI 45380) 的脂质微粒 (LM)，并研究该系统在模拟阳光或激光照射下对着色剂光稳定性的影响。使用三硬脂酸和磷脂酰胆碱作为赋形剂，通过熔融乳化制备负载 CI 45380 的 LM。它们通过光学显微镜、激光衍射、X 射线衍射和释放研究进行表征。用太阳模拟器或 Q 开关激光器照射游离 CI 45380 和加载了着色剂的 LM。用太阳模拟器辐照证明 CI 的光分解 通过在 LMs 中加入染料，45380 显着减少，从 20.5 ± 4.6% 到 1.3 ± 1.8%。相反，激光诱导的着色剂降解 (30.1 ± 6.6%) 不受 LM 封装的显着影响（封装的 CI 45380 损失为 27.4 ± 5.5%）。在脂质微粒中加入 CI 45380 可增强含有这种着色剂的纹身墨水在阳光下的光稳定性，而不影响其激光诱导降解，从而影响激光去除效率。
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