Sixty-four subacute stroke patients and 55 age-matched healthy controls (HCs) underwent a resting-state functional magnetic resonance imaging scan using an echo-planar imaging sequence and high-resolution sagittal T1-weighted images using a three-dimensional magnetization-prepared rapid gradient echo sequence. Static and dynamic voxel-mirrored homotopic connectivity (VMHC) was computed, respectively. The relationships between the clinical measures, including National Institutes of Health Stroke Scale (NIHSS), illness duration, Fugl-Meyer assessment for upper and lower extremities (FMA-total) and size of lesion volume, and the static/ dynamic VMHC variability alterations in stroke patients were calculated. The stroke patients showed significantly increased static VMHC in the corpus callosum, middle occipital gyrus and inferior parietal gyrus, and decreased static VMHC in the inferior temporal gyrus and precentral gyrus (PreCG) compared with those of HCs. For dynamic VMHC variability, increased dynamic VMHC variability in the inferior temporal gyrus and PreCG was detected in stroke patients relative to that in HCs. Correlation analysis exhibited that significant negative correlations were shown between the FMA scores and dynamic VMHC variability in PreCG. The present study suggests that combined static and dynamic VMHC could be helpful to evaluate the motor function of stroke patients and understand the intrinsic differences of inter-hemispheric coordination after stroke.

中文翻译：

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亚急性脑卒中患者的静态和动态体素镜像同位连接性改变：一项静止状态fMRI研究。

64位亚急性中风患者和55位年龄相匹配的健康对照（HCs）使用回波平面成像序列进行了静息状态功能磁共振成像扫描，并使用了三维磁化方法制备了高分辨率的矢状T1加权图像快速梯度回波序列。分别计算了静态和动态体素镜像同位连接性（VMHC）。临床测量之间的关系包括国立卫生研究院卒中量表（NIHSS），疾病持续时间，上肢和下肢的Fugl-Meyer评估（FMA-总）和病变体积的大小，以及静态/动态VMHC变异性变化之间的关系计算中风患者。中风患者的call体，枕中回和顶壁下回的静态VMHC显着增加，与HCs相比，颞下回和中央前回（PreCG）的静态VMHC降低。对于动态VMHC变异性，相对于HCs，在卒中患者中检测到颞下回和PreCG的动态VMHC变异性增加。相关分析表明，PreCG中的FMA评分与动态VMHC变异之间存在显着的负相关。本研究表明，静态和动态VMHC结合可能有助于评估中风患者的运动功能，并了解中风后半球间协调的内在差异。相对于HCs，在卒中患者中检测到颞下回和PreCG动态VMHC变异性增加。相关分析表明，PreCG中的FMA得分与动态VMHC变异之间存在显着的负相关。本研究表明，静态和动态VMHC结合可能有助于评估中风患者的运动功能，并了解中风后半球间协调的内在差异。相对于HCs，在卒中患者中检测到颞下回和PreCG动态VMHC变异性增加。相关分析表明，PreCG中的FMA得分与动态VMHC变异之间存在显着的负相关。本研究表明，静态和动态VMHC结合可能有助于评估中风患者的运动功能，并了解中风后半球间协调的内在差异。