The recent developments of clustered regularly interspaced short palindromic repeats(CRISPR)/-associate protein 9 (CRISPR/Cas9) have got scientific interests due to the straightforward, efficient and versatile talents of it. Furthermore, the CRISPR/Cas9 system has democratized access to gene editing in many biological fields, including cancer. Cancer development is a multistep process caused by innate and acquired mutations and leads to the initiation and progression of tumorigenesis. It is obvious that establishing appropriate animal cancer models which can simulate human cancers is crucial for cancer research currently. Since the emergence of CRISPR/Cas9, considerable efforts have been taken by researchers to apply this technology in generating animal cancer models. Although there is still a long way to go we are happy to see the achievements we have made and the promising future we have.

中文翻译：

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CRISPR / Cas9在动物癌症模型中的应用及进展。

簇状规则间隔的短回文重复序列（CRISPR）/相关蛋白9（CRISPR / Cas9）的最新发展由于其直接，高效和多用途的才能而引起了科学兴趣。此外，CRISPR / Cas9系统已使包括癌症在内的许多生物领域的基因编辑民主化。癌症发展是由先天和后天突变引起的多步骤过程，并导致肿瘤发生的开始和发展。显然，建立合适的可以模拟人类癌症的动物癌症模型对于当前的癌症研究至关重要。自从CRISPR / Cas9出现以来，研究人员已经做出了相当大的努力来将该技术应用于动物癌症模型的产生。