BACKGROUND Intracranial Atherosclerotic Stenosis (ICAS) is an important risk factor for cognitive impairment. However, it is unclear whether patients with ICAS are more likely to develop cognitive impairment after an acute, non-disabling ischemic stroke (minor stroke). OBJECTIVE We aimed to investigate the association between ICAS and post-stroke cognitive impairment. METHODS In this cross-sectional study, patients with acute, non-disabling ischemic stroke underwent two cognitive tests and imaging evaluation for ICAS, within two weeks after the stroke. To determine the association between ICAS and post-stroke cognitive impairment, we performed a multivariate logistic regression analysis adjusted for several demographic and vascular risk factors. RESULTS Of the 164 patients with minor stroke in this study, 98 (59.76%) were diagnosed with poststroke cognitive impairment (Montreal Cognitive Assessment score<26). After adjusting for potential confounders, we found that patients with ICAS were more likely to develop cognitive impairment after an acute, non-disabling ischemic stroke, compared to patients without ICAS (Odds Ratio: 2.13; 95% Confidence Interval: 1.07-4.26), and underperformed in the tests of visuospatial and executive function. CONCLUSION In this cross-sectional study of a population that has experienced a minor stroke, our findings demonstrated a positive association between ICAS and post-stroke cognitive impairment.

中文翻译：

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颅内动脉粥样硬化性狭窄与中风后认知障碍有关：横断面研究。

背景技术颅内动脉粥样硬化狭窄（ICAS）是认知障碍的重要危险因素。然而，尚不清楚ICAS患者在急性，非致残性缺血性中风（轻度中风）后是否更有可能出现认知障碍。目的我们旨在研究ICAS与中风后认知障碍之间的关系。方法在这项横断面研究中，患有急性非致残性缺血性中风的患者在中风后两周内接受了两次认知测试和ICAS影像学评估。为了确定ICAS与中风后认知障碍之间的关联，我们进行了多因素logistic回归分析，该分析针对多种人口统计学和血管危险因素进行了调整。结果在本研究的164例轻度中风患者中，有98例（59。76％的人被诊断出患有中风后认知障碍（蒙特利尔认知评估得分<26）。调整了潜在的混杂因素后，我们发现，与没有ICAS的患者相比，ICAS的患者在发生急性，非致残性缺血性卒中后更容易出现认知障碍（几率：2.13； 95％的置信区间：1.07-4.26），在视觉空间和执行功能的测试中表现不佳。结论在这项对中风较轻的人群进行的横断面研究中，我们的发现表明，ICAS与中风后认知障碍之间存在正相关。与没有ICAS的患者相比（非致残性缺血性卒中）（几率：2.13； 95％置信区间：1.07-4.26），并且在视觉空间和执行功能测试中表现不佳。结论在这项对中风较轻的人群进行的横断面研究中，我们的发现表明，ICAS与中风后认知障碍之间存在正相关。与没有ICAS的患者相比（非致残性缺血性卒中）（几率：2.13； 95％置信区间：1.07-4.26），并且在视觉空间和执行功能测试中表现不佳。结论在这项对中风较轻的人群进行的横断面研究中，我们的发现表明，ICAS与中风后认知障碍之间存在正相关。