We investigated the effects of melatonin on rats with induced hypothyroidism during gestation as well as its effect on the development of the gonads of their offspring. Fifteen pregnant rats were divided into three groups: GC, rats without induced hypothyroidism; GH, rats with induced hypothyroidism; GHM, rats with induced hypothyroidism plus melatonin. Hypothyroidism was induced by oral administration of 6-propyl-2-thiouracil and melatonin was applied subcutaneously. Treatments were performed during gestation and lactation. For the matrices, we evaluated the number of pups, body weight gain, ovarian weight, thyroid weight, organosomatic index, thyroid stimulating hormone (TSH) dose and thyroid morphometry. For the pups, weight gain, TSH, weight, morphometry of the gonads and organosomatic index were analyzed, as well as the cell proliferation index. TSH was elevated only in the matrices of GH animals. Melatonin prevented reduction of ovarian and thyroid weight, number of pups, follicular diameter and thyroid epithelial proportion of the matrices with hypothyroidism. The offspring of rats of the GH group exhibited less body weight gain, gonad and thyroid weight, and gonad cell proliferation index compared to the offspring born of rats of the GC and GHM groups. Melatonin prevented the effects of maternal hypothyroidism on the offspring of rats.

我们调查了褪黑激素对妊娠期甲状腺功能减退症大鼠的影响，及其对子代性腺发育的影响。将15只怀孕的大鼠分为三组：GC，无诱发甲状腺功能减退的大鼠；和 GH，诱发甲状腺功能减退的大鼠；GHM，诱发甲状腺功能减退的大鼠加褪黑激素。口服6-丙基-2-硫尿嘧啶可诱发甲状腺功能减退，并在皮下使用褪黑激素。在妊娠和哺乳期间进行治疗。对于基质，我们评估了幼崽的数量，体重增加，卵巢重量，甲状腺重量，有机体指数，甲状腺刺激激素（TSH）剂量和甲状腺形态。对于幼崽，分析了体重增加，TSH，体重，性腺的形态和有机体指数，以及细胞增殖指数。TSH仅在GH动物的基质中升高。褪黑素可防止甲状腺功能减退症患者的卵巢和甲状腺重量，幼崽数量，卵泡直径和甲状腺上皮比例减少。与GC和GHM组大鼠的后代相比，GH组大鼠的后代表现出较少的体重增加，性腺和甲状腺重量以及性腺细胞增殖指数。褪黑素可预防母体甲状腺功能减退对大鼠后代的影响。与GC和GHM组大鼠的后代相比，其生殖腺和甲状腺的重量以及生殖腺细胞的增殖指数。褪黑素可预防母体甲状腺功能减退对大鼠后代的影响。与GC和GHM组大鼠的后代相比，其生殖腺和甲状腺的重量以及生殖腺细胞的增殖指数。褪黑素可预防母体甲状腺功能减退对大鼠后代的影响。