The prevalence of azole resistance in C parapsilosis is very low in most parts of the world. However, South Africa has reported an exceptionally high prevalence of azole resistance in C parapsilosis strains isolated from candidaemia cases. We aimed to determine the possible molecular mechanisms of fluconazole resistance in C parapsilosis isolates obtained through surveillance at a large neonatal unit at a South African academic hospital.

中文翻译：

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ERG11 基因中 Y132F 取代的氟康唑耐药近平滑念珠菌菌株导致南非新生儿病房的侵袭性感染

在世界大部分地区，近平滑念珠菌中唑类耐药性的流行率非常低。然而，南非报告了从念珠菌血症病例中分离的近平滑念珠菌菌株中唑类耐药性的异常高发率。我们旨在确定通过在南非学术医院的大型新生儿病房监测获得的近平滑念珠菌分离株中氟康唑耐药性的可能分子机制。