Intolerance of uncertainty (IU) is a trait characteristic marked by distress in the face of insufficient information. Elevated IU has been implicated in the development and maintenance of anxiety disorders, particularly during adolescence, which is characterized by dramatic neural maturation and the onset of anxiety disorders. Previous task-based work implicates the bilateral anterior insula in IU. However, the association between anterior insula intrinsic functional connectivity (iFC) and IU has not been examined in adolescents. Fifty-eight healthy youth (mean age = 12.56; 55% boys) completed the Intolerance of Uncertainty Scale for Children (IUSC-12) and a 6-minute resting state fMRI scan. Group-level analyses were conducted using a random-effects, ordinary least-squares model, including IUSC-12 scores (Total, Inhibitory subscale, Prospective subscale), and three nuisance covariates (age, sex, and mean framewise displacement). IUSC-12 Inhibitory subscale scores were predictive of iFC between the left and right anterior insula and right prefrontal regions. IUSC-12 Prospective subscale scores significantly predicted iFC between the anterior insula and the anterior cingulate cortex. IUSC-12 total scores did not predict significant iFC of the bilateral anterior insula. Follow-up analyses, including anxiety (MASC Total Score) in the models, failed to find significant results. This could suggest that the associations found between IUSC-12 scores and anterior insula iFC are not unique to IU and, rather, reflect a broader anxiety-related connectivity pattern. Further studies with larger samples are needed to tease apart unique associations. These findings bear significance in contributing to the literature evaluating the neural correlates of risk factors for anxiety in youth.

不容忍不确定性（IU）是一种在信息不足时感到痛苦的特征。 IU 升高与焦虑症的发生和维持有关，特别是在青春期，其特点是神经急剧成熟和焦虑症的发作。先前基于任务的工作涉及 IU 的双侧前岛叶。然而，前岛叶固有功能连接 (iFC) 和 IU 之间的关联尚未在青少年中进行研究。 58 名健康青少年（平均年龄 = 12.56；55% 为男孩）完成了儿童不确定性耐受量表 (IUSC-12) 和 6 分钟静息态 fMRI 扫描。使用随机效应、普通最小二乘模型进行组水平分析，包括 IUSC-12 评分（总分、抑制子量表、前瞻性子量表）和三个讨厌的协变量（年龄、性别和平均框架位移）。 IUSC-12 抑制子量表评分可预测左右前岛叶和右前额叶区域之间的 iFC。 IUSC-12 前瞻性子量表评分显着预测前岛叶和前扣带皮层之间的 iFC。 IUSC-12 总分并不能预测双侧前岛叶的显着 iFC。后续分析，包括模型中的焦虑（MASC 总分），未能发现显着的结果。这可能表明 IUSC-12 评分与前岛叶 iFC 之间的关联并非 IU 所独有，而是反映了更广泛的与焦虑相关的连接模式。需要对更大的样本进行进一步的研究来梳理独特的关联。这些发现对于评估青少年焦虑危险因素的神经相关性的文献具有重要意义。