In this paper, we generalize a previous model of within-host dengue infection with a nonconstant monocyte production rate. We establish the existence of three equilibria and give some local stability results. We then estimate three parameters in the model from clinical data for dengue virus serotype 2. It is then shown that the model can exhibit behaviours that are not possible under the assumption of constant monocyte production. Lastly, we perform a sensitivity analysis of the model in two contexts, antiviral treatment and immunostimulatory treatment. The results predict that antiviral treatments that reduce the viral replication rate in infected monocytes are the most effective, while immunostimulatory treatments that increase the rate at which infected monocytes are removed are best.

中文翻译：

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具有非恒定单核细胞生产率的登革热感染的通用宿主内模型。

在本文中，我们推广了具有非恒定单核细胞生产率的宿主内登革热感染的先前模型。我们建立了三个平衡点的存在，并给出了一些局部稳定性结果。然后，我们从登革热病毒血清型2的临床数据估算模型中的三个参数。然后表明，该模型可以展现出在恒定单核细胞产量假设下不可能实现的行为。最后，我们在两种情况下对模型进行敏感性分析，即抗病毒治疗和免疫刺激治疗。结果预测，降低感染的单核细胞中病毒复制速率的抗病毒治疗最有效，而提高感染的单核细胞去除率的免疫刺激治疗效果最佳。