Intestinal helminth parasites present major challenges to the welfare of humans and threaten the global food supply. While the discovery of anthelminthic drugs empowered our ability to offset these harms to society, the alarming rise of anthelminthic drug resistance mitigates contemporary efforts to treat and control intestinal helminthic infections. Fortunately, emerging research points to potential opportunities to combat anthelminthic drug resistance by harnessing the gut microbiome as a resource for discovering novel therapeutics and informing responsible drug administration. In this review, we highlight research that demonstrates this potential and provide rationale to support increased investment in efforts to uncover and translationally utilize knowledge about how the gut microbiome mediates intestinal helminthic infection and its outcomes.

中文翻译：

---

利用肠道微生物组对抗驱虫药耐药性。

肠道蠕虫寄生虫对人类的福祉提出了重大挑战，并威胁着全球粮食供应。驱虫药的发现使我们有能力抵消对社会的危害，而驱虫药耐药性的惊人上升却减轻了当代治疗和控制肠道蠕虫感染的努力。幸运的是，新兴研究指出通过利用肠道微生物组作为发现新疗法并告知负责任的药物管理的资源，可以对抗驱虫药耐药性。在这篇综述中，我们重点介绍了证明这种潜力的研究，并提供了理论依据来支持加大投入，以发现和转化利用有关肠道微生物组如何介导肠道蠕虫感染及其后果的知识。