While phonologic errors may be one of the salient features of the logopenic variant of primary progressive aphasia (lvPPA), sparse data are available on their neuroimaging correlates. The purpose of this study was to identify brain regions associated with different types of phonologic errors across several tasks for participants with lvPPA. Correlational analyses between phonologic errors across tasks most likely to elicit such errors and specific left hemisphere gray matter volume regions were conducted for 20 participants. Findings point to the inferior parietal lobe and supramarginal gyrus as being the most relevant correlates. Atrophy in these regions may increase the likelihood of making phonologic errors in lvPPA, particularly substitution error types. Our results provide support for neuroanatomical correlates of phonologic errors in the parietal region, which is consistent with previous findings of temporoparietal cortex involvement/atrophy in lvPPA.

中文翻译：

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logopenic 进行性失语症语音错误的神经解剖学相关性

虽然语音错误可能是原发性进行性失语症 (lvPPA) 的 logopenic 变体的显着特征之一，但关于其神经影像相关性的数据很少。本研究的目的是确定与 lvPPA 参与者在多项任务中不同类型的语音错误相关的大脑区域。对 20 名参与者进行了最有可能引起此类错误的任务中的语音错误与特定的左半球灰质体积区域之间的相关性分析。研究结果指出顶下叶和缘上回是最相关的相关因素。这些区域的萎缩可能会增加在 lvPPA 中出现语音错误的可能性，尤其是替代错误类型。