Purpose: To examine thiol-disulphide homeostasis auto painters.Materials and methods: A total of 115 male workers, including 60 auto painters workers and 55 reference group, of the painting and assembly line units respectively, were included in the study. Thiol-disulphide parameters and ischaemia-modified albumin (IMA) of groups were determined. Urinary hippuric acid, (HA) phenol, hexanedione, trichloroacetic acid, arsenic and blood lead and manganese were analysed.Results: The median urinary HA level was significantly higher in auto painters when compared to the reference group [(2461 (1212) vs. 520 (513) µgr/L), (p < 0.001)] . The mean disulphide level [19.7 (4.3) vs 0.15.1(4.1) μmol/L, (p < 0.001)], the disulphide/native thiol ratio [4.72 (1.47) vs. 3.13 (1.21, (p < 0.001)] and the disulphide/total thiol ratio [4.31 (1.23) vs. 2.94 (1.06), (p < 0.001)] were higher in auto painters when compared to the reference group. There was a statistically significant positive correlation between urinary HA and disulphide concentrations (r = 0.536 and p < 0.001), disulphide/native thiol ratio (r = 0.564 and p < 0.001) and the disulphide/total thiol ratio (r = 0.564 and p < 0.001) and IMA (r = 0.396 and p < 0.001).Conclusion: The results presented in this study showed that oxidative stress can be associated with occupational exposure to toluene denoted by alteration of thiol disulphide homeostasis and ischaemia-modified albumin levels.

中文翻译：

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动态硫醇/二硫化物稳态作为汽车工人氧化应激的指标。

目的：研究硫醇-二硫化物稳态汽车油漆工。材料与方法：研究对象共115名男性工人，其中分别包括60名汽车油漆工和55个参考组。确定组的巯基二硫化物参数和局部缺血修饰的白蛋白（IMA）。分析了尿中的马尿酸，（HA）苯酚，己二酮，三氯乙酸，砷和血铅和锰。结果：与参考组相比，汽车油漆匠的尿中HA含量中位数显着高于[[2461（1212）vs. 520（513）µgr / L），（p <0.001）]。平均二硫化物含量[19.7（4.3）vs 0.15.1（4.1）μmol/ L，（p <0.001）]，二硫化物/天然硫醇比[4.72（1.47）vs 3.13（1.21，（p <0.001）]以及二硫键/总硫醇比[4.31（1.23）对2.94（1。06），（p <0.001）]与参考组相比在自动喷漆机中更高。尿中HA和二硫化物浓度（r = 0.536和p <0.001），二硫化物/天然硫醇比（r = 0.564和p <0.001）与二硫化物/总硫醇比（r = 0.564和p）之间存在统计学上的显着正相关结论：本研究结果表明，氧化应激可能与甲苯职业暴露相关，其特征在于硫醇二硫化物体内稳态的改变和局部缺血修饰的白蛋白水平。（<0.001）和IMA（r = 0.396，p <0.001）。