OBJECTIVES To compare eccentric (ECC) and conventional concentric (CON) cycle training on quadriceps muscle strength in advanced COPD. Secondary objective was to assess functional capacity. METHODS A parallel-group, assessor-blind, randomized trial was conducted. Severe COPD patients were randomized to either an ECC (n = 13) or CON (n = 11) cycling program for 30-min, 3 times/week for 10 weeks. ECC group trained at ∼4-fold higher power than the CON group at similar relative heart rate intensity. RESULTS Isometric and isokinetic quadriceps peak torque improved after ECC but not CON; between group difference was significant for isometric peak muscle force (p < 0.05). Peak cycling power and endurance time increased in both groups (p < 0.05). Dyspnea at peak cycling power improved only after ECC training (p < 0.05). Sensory intensity ratings of dyspnea and leg fatigue were significantly lower (p < 0.05) during ECC compared with CON at equivalent relative heart rate intensities. CONCLUSIONS ECC could be an effective alternative and/or adjunct modality to pulmonary rehabilitation in severely ventilatory limited COPD patients.

中文翻译：

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偏心与传统循环训练改善晚期 COPD 的肌肉力量：一项随机临床试验。

目的 比较偏心 (ECC) 和传统的向心 (CON) 循环训练对晚期 COPD 股四头肌力量的影响。次要目标是评估功能能力。方法 进行了一项平行组、评估者盲法、随机试验。重度 COPD 患者被随机分配到 ECC（n = 13）或 CON（n = 11）循环计划中，每次 30 分钟，每周 3 次，共 10 周。ECC 组在相似的相对心率强度下以比 CON 组高约 4 倍的功率进行训练。结果 ECC 后等长和等速股四头肌峰值扭矩有所改善，但 CON 没有改善；组间差异对于等长峰值肌肉力是显着的（p < 0.05）。两组的峰值循环功率和耐力时间均增加（p < 0.05）。峰值循环功率下的呼吸困难仅在 ECC 训练后改善（p < 0.05）。与同等相对心率强度下的 CON 相比，ECC 期间呼吸困难和腿部疲劳的感觉强度等级显着降低（p < 0.05）。结论 ECC 可能是严重通气受限的 COPD 患者肺康复的有效替代和/或辅助方式。