Solid State Nuclear Magnetic Resonance ( IF 1.8 ) Pub Date : 2020-01-11 , DOI: 10.1016/j.ssnmr.2020.101642 Anuji Abraham 1 , Eric Chan 1 , Hyunsoo Park 1
Characterization of lipid based (SPC/GDO/H2O) liquid crystal (LC) drug delivery system is non-trivial and highly complex, especially when multiple and intermediate phases are present. The phase behavior of such mixtures during hydration or delivery is still poorly understood and therefore, characterizing these systems is crucially important towards controlling their function and enhancing the understanding of their drug release behavior. Current work has established an easy way to identify liquid crystal phases and phase mixtures using deuterium (2H) solid-state nuclear magnetic (NMR) spectroscopy under static conditions without disrupting the three dimensional structure and phases, as magic-angle spinning (MAS) could lead to disruption of the phases. Small angle X-ray scattering (SAXS) technique and optical microscopy were also employed to corroborate the study.
中文翻译:
使用氘固体NMR快速了解液晶药物输送系统中的相和相分离。
基于脂质的(SPC / GDO / H 2 O)液晶(LC)药物传递系统的表征并非无关紧要且高度复杂,特别是在存在多个中间相的情况下。在水化或输送过程中,此类混合物的相行为仍然知之甚少,因此,表征这些系统对于控制其功能和增强对药物释放行为的理解至关重要。当前的工作已经建立了一种使用氘来识别液晶相和相混合物的简便方法(2H)在静态条件下的固态核磁(NMR)光谱,而不会破坏三维结构和相,因为魔角旋转(MAS)可能导致相的破坏。小角X射线散射(SAXS)技术和光学显微镜也被用来证实这项研究。