Hemicentins (HMCNs) are a family of extracellular matrix proteins first identified in Caenorhabditis elegans , with two orthologs (HMCN1 and 2) in vertebrates. In worms, HMCN is deposited at specific sites where it forms long, fine tracks that link two tissues by connecting adjacent basement membranes (BMs). By generating CRISPR/Cas9‐mediated Hmcn1 and Hmcn2 knockout mice, we tested the hypothesis that HMCNs perform similar functions in mammals.

中文翻译：

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哺乳动物半霉素1在多种组织的细胞外基质中组装成轨道。

Hemicentins（HMCNs）是最早在秀丽隐杆线虫中鉴定的细胞外基质蛋白家族，在脊椎动物中有两个直系同源物（HMCN1和2）。在蠕虫中，HMCN沉积在特定的位置，在此处形成长而细的轨道，通过连接相邻的基底膜（BM）来连接两个组织。通过产生CRISPR / Cas9介导的Hmcn1和Hmcn2敲除小鼠，我们测试了HMCN在哺乳动物中执行类似功能的假设。