ADP-ribosylation is an intricate and versatile posttranslational modification involved in the regulation of a vast variety of cellular processes in all kingdoms of life. Its complexity derives from the varied range of different chemical linkages, including to several amino acid side chains as well as nucleic acids termini and bases, it can adopt. In this review, we provide an overview of the different families of (ADP-ribosyl)hydrolases. We discuss their molecular functions, physiological roles, and influence on human health and disease. Together, the accumulated data support the increasingly compelling view that (ADP-ribosyl)hydrolases are a vital element within ADP-ribosyl signaling pathways and they hold the potential for novel therapeutic approaches as well as a deeper understanding of ADP-ribosylation as a whole.

中文翻译：

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（ADP-核糖基）水解酶：结构、功能和生物学。

ADP-核糖基化是一种复杂且多功能的翻译后修饰，涉及所有生命王国中各种细胞过程的调节。它的复杂性源于不同范围的不同化学键，包括几个氨基酸侧链以及核酸末端和碱基，它可以采用。在这篇综述中，我们概述了（ADP-核糖基）水解酶的不同家族。我们讨论了它们的分子功能、生理作用以及对人类健康和疾病的影响。总之，累积的数据支持越来越令人信服的观点，即（ADP-核糖基）水解酶是 ADP-核糖基信号通路中的一个重要元素，它们具有开发新治疗方法的潜力以及对 ADP-核糖基化整体的更深入理解。