The purpose of this study was to evaluate the kinetic parameters that determine the uptake rate of radioiodide in the thyroid over 24 h after administration and to estimate thyroid volumes/masses of present-day Japanese. Methods: We determined the thyroid uptake rate of I in healthy male Japanese after oral administration (4.5-8.0 MBq) without iodine restriction. Masses of thyroid glands were collected in 2012-2016 during autopsies of 7,651 male and 3,331 female subjects. Volumes of thyroid glands were estimated by ultrasonography and magnetic resonance imaging in 52 male subjects. Results: The thyroid uptake rate of I for 24 h was 16.1 ± 5.4%. Kinetic model analysis was conducted to obtain the clearances (L h) for thyroid uptake and urinary excretion of I (0.499 ± 0.258 and 2.10 ± 0.39 L h, respectively). The masses of thyroid glands were on average 19.8 g (95% confidence interval of 18.3-19.5 g) and 15.5 g (95% confidence interval of 14.7-16.2 g) in male and female subjects aged 19-52 y, respectively. Volumes of thyroid glands estimated by ultrasonography and magnetic resonance imaging were 17.5 ± 5.2 and 14.2 ± 5.3 mL, respectively. In healthy Japanese, there has been no significant change for at least 50 y in the thyroid uptake of radioiodide over 24 h or in its kinetic parameters. These Japanese-specific kinetic parameters will allow quantitative estimation of the radiation exposure from the Fukushima accident and its variance during the individual's evacuation from or stay in Fukushima.

中文翻译：

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确定当前健康的日本志愿者中甲状腺，甲状腺重量和甲状腺体积的123I摄取动力学参数。

这项研究的目的是评估动力学参数，以确定给药后24小时内甲状腺中放射性碘的吸收率，并评估当今日本人的甲状腺体积/质量。方法：我们测定了无碘限制的健康男性日本人口服（4.5-8.0 MBq）后甲状腺的I摄取率。在2012-2016年期间对7,651名男性和3,331名女性受试者进行了尸体解剖，收集了大量甲状腺。通过超声检查和磁共振成像对52名男性受试者的甲状腺体积进行了估计。结果：24小时的I甲状腺摄取率为16.1±5.4％。进行动力学模型分析以获得I的甲状腺摄取和尿排泄的清除率（L h）（分别为0.499±0.258和2.10±0.39 L h）。在19-52岁的男性和女性受试者中，甲状腺的平均质量分别为19.8 g（95％置信区间18.3-19.5 g）和15.5 g（95％置信区间14.7-16.2 g）。通过超声检查和磁共振成像估计的甲状腺体积分别为17.5±5.2和14.2±5.3 mL。在健康的日本人中，放射性碘在24小时内的甲状腺摄取量或动力学参数在至少50 y内没有显着变化。这些日本特有的动力学参数将可以定量估计福岛事故造成的辐射暴露及其在人员从福岛撤离或停留在福岛期间的变化。分别。通过超声检查和磁共振成像估计的甲状腺体积分别为17.5±5.2和14.2±5.3 mL。在健康的日本人中，放射性碘在24小时内的甲状腺摄取量或动力学参数在至少50 y内没有显着变化。这些日本特定的动力学参数将可以定量估计从福岛事故中撤离或留在福岛事故中福岛事故的辐射暴露及其变化。分别。通过超声检查和磁共振成像估计的甲状腺体积分别为17.5±5.2和14.2±5.3 mL。在健康的日本人中，放射性碘在24小时内的甲状腺摄取量或动力学参数在至少50 y内没有显着变化。这些日本特有的动力学参数将可以定量估计福岛事故造成的辐射暴露及其在人员从福岛撤离或停留在福岛期间的变化。