The distinctive segregation patterns of chromosomes in mitosis and meiosis are dictated in part by the kinetochores, the structures on chromosomes that attach them to the microtubules of the spindle. Inappropriate mitosis-like chromosome segregation in meiosis leads to gametes with incorrect chromosome numbers. New findings by Chen and colleagues (pp. 209-225) in this issue of Genes & Development reveal how cells restructure their kinetochores when they enter meiosis. Their results describe an interconnected set of mechanisms that provides multiple layers of protection from the carryover of mitotic chromosome segregation patterns into meiotic cells.

中文翻译：

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安全总比遗憾地阻止减数分裂染色体的有丝分裂分离更好。


有丝分裂和减数分裂中染色体独特的分离模式部分是由动粒决定的，动粒是染色体上将染色体附着在纺锤体微管上的结构。减数分裂中不适当的有丝分裂样染色体分离导致配子的染色体数目不正确。 Chen 及其同事在本期《基因与发育》中的新发现（第 209-225 页）揭示了细胞在进入减数分裂时如何重组其动粒。他们的结果描述了一组相互关联的机制，这些机制提供了多层保护，防止有丝分裂染色体分离模式转移到减数分裂细胞中。