The combined frequencies of the IL-6 G-174C and IGFBP3 A-202C polymorphisms among swimmers and runners.,Growth Hormone and IGF Research

当前位置： X-MOL 学术 › Growth Horm. IGF Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The combined frequencies of the IL-6 G-174C and IGFBP3 A-202C polymorphisms among swimmers and runners.
Growth Hormone and IGF Research ( IF 1.6 ) Pub Date : 2020-01-14 , DOI: 10.1016/j.ghir.2020.01.002
Sigal Ben-Zaken ₁ , Yoav Meckel ₁ , Dan Nemet ₂ , Eias Kassem ₃ , Alon Eliakim ₃

Affiliation

Previous studies have demonstrated that compared to runners, swimmers carry a higher prevalence of the IL-6 -174C polymorphism and lower single nucleotide polymorphism frequencies of the IGF system.

Purpose

The aim of the present study was to assess the combined frequency of the IL-6 -174G/C and IGFBP3 -202A/C polymorphisms among track and field athletes and swimmers.

Methods

Track and field athletes were divided into long-distance runners (major event 5000 m-marathon, n = 63) and power athletes (major event 100-200 m sprints and long jump, n = 67). Swimmers were divided into long-distance swimmers (major event: 400-1500 m, n = 50), and short-distance swimmers (major event: 50-100 m, n = 43). All participants had achieved results that ranked them among the top all-time Israeli athletes in their event, and competed at national and/or international level on a regular basis.

Results

Carrying both IL-6C and IGFBP3C mutations was significantly greater among long-distance swimmers (LDS – 44%) compared to long distance runners (LDR – 21%, p < .01), and among short distance swimmers (SDS – 49%) compared to sprinters and jumpers (S/J – 28%, p < .05). Among runners, the prevalence of those not carrying either of the two mutations was significantly higher among LDR (25%) compared to S/J (10%, p < .03).

Conclusion

The prevalence of carrying both IL-6C and IGFBP3C mutations was significantly higher among the swimmers compared to runners. It is possible that carrying the IGFBP3C polymorphism is required to compensate for the potential genetically non-beneficial effects of a higher IL-6C genotype and an attenuated IGF system among the swimmers.

中文翻译：

游泳者和跑步者中IL-6 G-174C和IGFBP3 A-202C多态性的组合频率。

先前的研究表明，与跑步运动员相比，游泳运动员的IL-6 -174C多态性患病率更高，而IGF系统的单核苷酸多态性患病率更低。

目的

本研究的目的是评估田径运动员和游泳者IL-6 -174G / C和IGFBP3 -202A / C多态性的组合频率。

方法

田径运动员分为长跑运动员（主要项目5000 m马拉松，n = 63）和力量运动员（主要项目100-200 m sprint和跳远，n = 67）。游泳者分为长距离游泳者（主要事件：400-1500 m，n = 50）和短距离游泳者（主要事件：50-100 m，n = 43）。所有参与者都取得了成绩，使他们跻身以色列历史上最优秀的运动员之列，并定期参加国家和/或国际比赛。

结果

与长距离跑步者（LDR – 21％，p <.01）相比，长距离游泳者（LDS – 44％）和短距离游泳者（SDS – 49）携带IL-6 C和IGFBP3 C突变的比例明显更高。％）与短跑和跳投相比（S / J – 28％，p <.05）。在跑步者中，与S / J（10％，p <.03）相比，LDR（25％）中未携带两种突变者的患病率明显更高。