INTRODUCTION A body of evidence suggests that exposure to psychosocial stressors and stress sensitivity are involved in psychosis pathogenesis. However, little is known about the temporal course of these domains in those with psychosis-risk syndromes. Further, to date there have been no studies examining associations between psychosocial stressors and impaired stress tolerance, or how these factors might be implicated in symptom progression prior to psychosis onset. METHODS A total of 73 clinical high-risk (CHR) participants and 78 healthy controls (HC) completed baseline measures of life-event (LE) exposure and impaired stress tolerance. Additionally, 54 CHR and 57 HC participants returned to complete the same procedures at a 12-month follow-up assessment. RESULTS Results indicated that when compared to HCs, CHR individuals exhibited increased LE exposure and impaired stress tolerance at baseline. Longitudinal analyses compared subgroups of CHR participants who exhibited positive symptoms worsening over the one-year course (CHR-Prog), improved or steady (CHR-Remiss/Persist), and HCs. CHR-Prog individuals showed consistently elevated independent LEs exposure while CHR-Remiss/Persist reported a decline and HCs a steady low level across time. Further, CHR-Prog exhibited increased stress intolerance, while the CHR-Remiss/Persist improved and HCs displayed consistently low levels over time. Analyses examining interrelationships between these domains showed a trend level interaction effect predicting follow-up symptoms. DISCUSSION Taken together, results from the present study indicate an important role for exposure to stressors and increasing stress intolerance during psychosis pathogenesis. Additionally, findings indicating decreases in stress exposure may lead to more favorable outcomes provide a promising target for novel targeted interventions.

中文翻译：

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临床精神病高风险个体持续暴露于心理社会压力源和进行性的压力不耐受。


引言 大量证据表明，暴露于心理社会压力源和压力敏感性与精神病的发病机制有关。然而，对于患有精神病风险综合征的人这些领域的时间过程知之甚少。此外，迄今为止，还没有研究探讨心理社会压力源与应激耐受力受损之间的关联，或者这些因素如何与精神病发作前的症状进展有关。方法 共有 73 名临床高风险 (CHR) 参与者和 78 名健康对照 (HC) 完成了生活事件 (LE) 暴露和应激耐受力受损的基线测量。此外，54 名 CHR 和 57 名 HC 参与者返回并在 12 个月的随访评估中完成相同的程序。结果 结果表明，与 HC 相比，CHR 个体在基线时表现出 LE 暴露增加和应激耐受力受损。纵向分析比较了 CHR 参与者的亚组，这些亚组在一年的过程中表现出阳性症状恶化（CHR-Prog）、改善或稳定（CHR-Remiss/Persist）以及 HC。 CHR-Prog 个体表现出持续升高的独立 LE 暴露，而 CHR-Remiss/Persist 报告下降，HC 随时间稳定在低水平。此外，CHR-Prog 表现出增加的压力不耐受性，而 CHR-Remiss/Persist 有所改善，并且 HC 随着时间的推移表现出持续的低水平。检查这些领域之间相互关系的分析显示了预测后续症状的趋势水平交互作用。讨论 综上所述，本研究的结果表明，在精神病发病机制中，暴露于压力源和增加压力不耐受具有重要作用。 此外，研究结果表明，压力暴露的减少可能会带来更有利的结果，为新型针对性干预措施提供了一个有希望的目标。