Introduction: Various pharmaceutical preparations are widely used for clinical treatment. Elucidation of the mechanisms of drug release and evaluation of drug efficacy in biological samples are important in drug design and drug quality control.Areas covered: This review classifies recent applications of Fourier transform infrared (FTIR) spectroscopy in the field of medicine to comprehend drug release and diffusion. Drug release is affected by many factors of preparations, such as drug delivery system and microstructure polymorphism. The applications of FTIR imaging and nano-FTIR technique in biological samples lay a foundation for studying drug mechanism in vivo.Expert opinion: FTIR spectroscopy meets the research needs on preparations to understand the processes and mechanisms underlying drug release. The combination of attenuated total reflectance-FTIR imaging and nano-FTIR accompanied by chemometrics is a potent tool to overcome the deficiency of conventional infrared detection. FTIR shows an enormous potential in drug characterization, drug quality control, and bio-sample detection.

中文翻译：

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傅里叶变换红外光谱在药物制剂中的应用。

简介：各种药物制剂被广泛用于临床治疗。阐明药物释放的机制和评估生物样品中的药物效力对于药物设计和药物质量控制非常重要。涵盖的领域：本综述对傅里叶变换红外（FTIR）光谱学在医学领域中了解药物释放的最新应用进行了分类和扩散。药物释放受制剂的许多因素影响，例如药物递送系统和微结构多态性。FTIR成像和纳米FTIR技术在生物样品中的应用为研究体内药物机理奠定了基础。专家意见：FTIR光谱学满足制备研究的需要，以了解药物释放的过程和机理。衰减全反射FTIR成像和纳米FTIR结合化学计量学的结合是一种有效的工具，可以克服常规红外检测的不足。FTIR在药物表征，药物质量控制和生物样品检测方面显示出巨大潜力。