Tachykinins (TKs) are a family of neuropeptides mainly expressed by neuronal and non-neuronal cell types, especially immune cells. Expression of TKs receptors on immune cell surfaces, their involvement in immune-related disorders, and therefore, understanding their immunomodulatory roles have become of particular interest to researchers. In fact, the precise understanding of TKs intervention in the immune system would help to design novel therapeutic approaches for patients suffering from immune disorders. The present review summarizes studies on TKs function as modulators of the immune system by reviewing their roles in generation, activation, development, and migration of immune cells. Also, it discusses TKs involvement in three main cellular mechanisms including inflammation, apoptosis, and proliferation.

中文翻译：

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速激肽及其受体的免疫调节作用。

速激肽 (TKs) 是一个主要由神经元和非神经元细胞类型，尤其是免疫细胞表达的神经肽家族。TKs 受体在免疫细胞表面的表达、它们与免疫相关疾病的参与，以及因此，了解它们的免疫调节作用已成为研究人员特别感兴趣的。事实上，对 TK 干预免疫系统的准确理解将有助于为患有免疫疾病的患者设计新的治疗方法。本综述通过回顾 TK 在免疫细胞的产生、激活、发育和迁移中的作用，总结了关于 TK 作为免疫系统调节剂的研究。此外，它还讨论了 TK 参与三种主要细胞机制，包括炎症、细胞凋亡和增殖。