Benefits of hypothermia in neonatal arterial ischemic strokes: a preclinical study,International Journal of Developmental Neuroscience

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Benefits of hypothermia in neonatal arterial ischemic strokes: a preclinical study
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-03-24 , DOI: 10.1002/jdn.10022
Mathilde Chevin ₁ , Stéphane Chabrier _{1,

2,

3} , Mickaël Dinomais _{4,

5} , Barry J Bedell ₆ , Guillaume Sébire ₁

Affiliation

There is currently no targeted treatment available for neonatal arterial ischemic strokes (NAIS). Epidemiological studies demonstrated that perinatal infection/inflammation, peripartum hypoxia, and occlusion of the internal carotid tree are the main determinants of NAIS. The well‐established benefit of therapeutic hypothermia (HT) in neonatal encephalopathy due to diffuse hypoxia‐ischemia provides a rationale for the potential use of HT as a neuroprotective strategy in NAIS.

中文翻译：

低温对新生儿动脉缺血性卒中的益处：一项临床前研究

目前没有针对新生儿动脉缺血性卒中 (NAIS) 的靶向治疗。流行病学研究表明，围产期感染/炎症、围产期缺氧和颈内动脉树闭塞是 NAIS 的主要决定因素。治疗性低温 (HT) 对弥漫性缺氧缺血引起的新生儿脑病的公认益处为 HT 作为 NAIS 中的神经保护策略的潜在用途提供了理论依据。

更新日期：2020-03-24

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