PURPOSE To analyze the association between pubertal stage, menstrual cycle and migraine attacks in girls with migraine. In addition, headache frequency, accompanying symptoms, duration and onset in relation to the specific phase of the cycle were investigated. METHODS Girls between 7 and 18 years old, diagnosed with headaches that met "International Classification of Headache Disorders II" diagnostic criteria for migraine without aura, kept a daily headache and menstrual cycle diary over 8 weeks. Ovulatory cycles were identified by weekly progesterone saliva tests. RESULTS 47 girls participated in the study and were divided into three groups according to Tanner stage and onset of regular menstruation: pre- (n = 16), peri- (n = 19) and post-pubertal (n = 12). A significant difference in migraine frequency was found between pre- and post-pubertal girls (p = 0.005). No significant differences with regard to headache characteristics were detected. Interestingly, a higher frequency of attacks in follicular phase occurred compared to luteal phase in peri- and post-pubertal girls (p = 0.030). CONCLUSION During puberty, migraine patterns in girls change to a typical adult pattern of migraine in a stepwise manner not clearly related to menarche. The first sign of this transition phase could be the higher frequency of migraine attacks in post-pubertal girls.

中文翻译：

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青少年偏头痛的表现：它会在青春期发生变化吗？

目的分析偏头痛女孩青春期、月经周期和偏头痛发作之间的关系。此外，还研究了与周期特定阶段相关的头痛频率、伴随症状、持续时间和发作。方法 7-18岁的女孩，被诊断为符合“国际头痛疾病分类II”无先兆偏头痛诊断标准的头痛，每天记录头痛和月经周期日记超过8周。通过每周孕酮唾液测试确定排卵周期。结果 47 名女孩参加了研究，并根据 Tanner 分期和正常月经的开始分为三组：前 (n = 16)、围 (n = 19) 和青春期后 (n = 12)。青春期前和青春期后女孩的偏头痛频率存在显着差异（p = 0.005）。没有检测到头痛特征的显着差异。有趣的是，与青春期前后女孩的黄体期相比，卵泡期发作的频率更高（p = 0.030）。结论 在青春期，女孩的偏头痛模式逐渐转变为典型的成人偏头痛模式，与初潮没有明显关系。这一过渡阶段的第一个迹象可能是青春期后女孩偏头痛发作的频率更高。结论 在青春期，女孩的偏头痛模式逐渐转变为典型的成人偏头痛模式，与初潮没有明显关系。这一过渡阶段的第一个迹象可能是青春期后女孩偏头痛发作的频率更高。结论 在青春期，女孩的偏头痛模式逐渐转变为典型的成人偏头痛模式，与初潮没有明显关系。这一过渡阶段的第一个迹象可能是青春期后女孩偏头痛发作的频率更高。