Objectives: To assess the evidence for the safety of intravenous iron infusions in patients with rheumatoid arthritis.Methods: A systematic literature search was performed in June 2019 on PubMed and Cochrane databases for eligible studies.Results: There is significant evidence of safety and efficacy of intravenous iron in patients with rheumatoid arthritis using newer, less immunogenic iron preparations, such as iron sucrose and low molecular weight iron dextran preparations.Discussion: Iron deficiency anaemia has a significant impact on the quality of life of patients with rheumatoid arthritis, but the use of intravenous iron is generally avoided due to concerns raisedin older studies using high molecular weight iron dextran of exacerbating the disease. However, such concerns have not been confirmed in more recent studies using newer preparations.Conclusion: We find significant evidence of safety and efficacy in more recent studies of larger cohorts of patients using newer, less immunogenic iron preparations.

中文翻译：

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类风湿关节炎患者现代静脉铁剂输注的安全性-文献综述。

目的：评估类风湿关节炎患者静脉输注铁的安全性的方法。方法：2019年6月在PubMed和Cochrane数据库中进行了系统的文献检索，以进行合格研究。结果：有明显的证据证明风湿性关节炎的安全性和有效性类风湿关节炎患者使用较新的，免疫原性较低的铁制剂（例如蔗糖铁和低分子量右旋糖酐铁制剂）静脉注射铁。讨论：缺铁性贫血对类风湿关节炎患者的生活质量有重大影响，但使用由于在较早的研究中使用高分子量右旋糖酐铁加剧了疾病的关注，通常避免使用静脉注射铁。但是，在使用较新制剂的最新研究中尚未证实这种担忧。