As the most common non-traumatic disabling disease among adolescents, multiple sclerosis (MS) is a devastating neurological inflammatory disease of the central nervous system. Research has not yet fully elucidated its pathogenesis, but it has shown MS to be a complex, multifactorial disease with many interplaying factors. One of these factors, natural killer (NK) cells, lymphocytes of the innate immune system, have recently gained attention due to the effects of daclizumab therapy, causing an expansion of the immunoregulatory subset of NK cells. Since then, NK cells and their relation to MS have been the focus of research, with many new findings being published in the last decade. In this review, NK cells are pictured as potent cytotoxic killers, as well as unique immune-regulators. Additionally, an overview of our current knowledge regarding NK cells in MS is given. The role of NK cells in MS is reviewed in the context of well-established environmental factors and current disease modifying therapies to gain further understanding of the pathogenesis and treatment options in MS.

中文翻译：

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多发性硬化中的自然杀伤细胞：综述。

作为青少年中最常见的非创伤性致残疾病，多发性硬化症（MS）是中枢神经系统的毁灭性神经炎性疾病。研究尚未完全阐明其发病机理，但已表明MS是具有许多相互作用因素的复杂的多因素疾病。这些因素之一，自然杀伤（NK）细胞，先天免疫系统的淋巴细胞，由于达珠单抗疗法的作用，最近引起了人们的关注，引起了NK细胞免疫调节亚群的扩大。从那时起，NK细胞及其与MS的关系一直是研究的重点，在过去十年中发表了许多新发现。在这篇综述中，NK细胞被描绘为有效的细胞毒性杀手，以及独特的免疫调节剂。另外，概述了我们目前有关MS中NK细胞的知识。NK细胞在MS中的作用已在公认的环境因素和当前的疾病改良疗法中进行了综述，以进一步了解MS的发病机理和治疗选择。