The spatial network structure of Dergall is based on substances nontoxic to humans and the environment which, when applied on solid surfaces, creates a coating that reduces bacterial cell adhesion. The bacteriostatic properties of siloxanes are based on a purely physical action mechanism which excludes development of drug-resistant microorganisms. The aims of the present study were to 1) evaluate a Dergall layer formed on the eggshell surface regarding the potential harmful effects on the chick embryo; 2) evaluate antimicrobial activity and estimate the prolongation time of Dergall's potential antimicrobial activity. Dergall at a concentration of 0.6% formed a layer on the eggshell surface. In vitro testing of the potential harmful effects of Dergall by means of a hen embryo test of the chorioallantoic membrane showed no irritation reaction at a concentration of 3% and lower. The hatchability of the groups sprayed with a Dergall water solution with a concentration of 0 to 5% was 89.1 to 93.8% for fertilized eggs (P > 0.05) but decreased to 63.7% (P < 0.05) in the group sprayed with a 6% concentration of the solution. This phenomenon was caused by embryo mortality in the first week of incubation. At the concentration of 0.6%, Dergall exhibited strong antibacterial properties against bacteria such as Staphylococcus aureus, Escherichia coli, Shigella dysenteriae, Shigella flexneri, and Salmonella typhimurium. For Streptococcus pyogenes, the highest antibacterial activity of Dergall was reported in the concentrations of 100 and 50%. For Pseudomonas aeruginosa, no antibacterial activity of Dergall was generally observed, but in vivo testing showed a strong decrease of all gram-negative bacteria growth. Moreover, a prolonged antimicrobial effect lasting until 3 D after disinfection was observed, which makes Dergall a safe and efficient disinfectant.

中文翻译：

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3维网络结构硅氧烷Dergall制剂对鸡胚发育和蛋壳微生物状况应用的初步评价。

Dergall 的空间网络结构基于对人类和环境无毒的物质，当应用于固体表面时，会形成一层减少细菌细胞粘附的涂层。硅氧烷的抑菌特性基于纯粹的物理作用机制，排除了耐药微生物的产生。本研究的目的是 1) 评估蛋壳表面形成的 Dergall 层对鸡胚胎的潜在有害影响；2)评价抗菌活性并估计Dergall潜在抗菌活性的延长时间。浓度为 0.6% 的 Dergall 在蛋壳表面形成一层。通过母鸡胚胎绒毛尿囊膜试验对 Dergall 的潜在有害影响进行的体外测试显示，在 3% 及更低的浓度下没有刺激反应。喷洒浓度为 0 至 5% 的 Dergall 水溶液的组受精卵孵化率为 89.1 至 93.8%（P > 0.05），但喷洒浓度为 6% 的 Dergall 水溶液组的孵化率下降至 63.7%（P < 0.05）。溶液的浓度。这种现象是由于孵化第一周胚胎死亡造成的。在0.6%的浓度下，Dergall对金黄色葡萄球菌、大肠杆菌、痢疾志贺氏菌、福氏志贺氏菌和鼠伤寒沙门氏菌等细菌表现出很强的抗菌性能。对于化脓性链球菌，据报道 Dergall 在 100% 和 50% 浓度时抗菌活性最高。对于铜绿假单胞菌，一般没有观察到 Dergall 的抗菌活性，但体内测试显示所有革兰氏阴性菌的生长均显着减少。此外，观察到消毒后持续3天的长效抗菌作用，这使得Dergall成为一种安全有效的消毒剂。