Therapeutic strategies and study designs for neurodegenerative diseases have started to explore the potential of preventive treatment in healthy people, emphasising characterisation of biomarkers capable of indicating proximity to clinical onset. This need is even more pressing for individuals at risk of prion disease given its rarity which virtually precludes the probability of recruiting enough numbers for well powered preventive trials based on clinical endpoints. Experimental mouse inoculation studies have revealed a rapid exponential rise in infectious titres followed by a relative plateau of considerable duration before clinical onset. This clinically silent incubation period represents a potential window of opportunity for the adaptation of ultrasensitive prion seeding assays to define the onset of prion infection, and for neurodegenerative biomarker discovery through similarly sensitive digital immunoassay platforms.

中文翻译：

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pr病毒感染和神经变性的临床前生物标志物。

神经退行性疾病的治疗策略和研究设计已开始探索对健康人进行预防性治疗的潜力，强调了能够指示接近临床发作的生物标志物的表征。鉴于病毒的罕见性，这实际上使处于pressing病毒疾病风险中的个体的需求更加迫切，这实际上排除了基于临床终点为功能强大的预防性试验招募足够数量的可能性的可能性。实验性小鼠接种研究显示，在临床发作之前，感染滴度迅速呈指数级上升，随后持续相当长时间。这个临床上静默的潜伏期为适应超敏感病毒播种测定法以定义病毒感染的发作提供了一个潜在的机会窗口，