The highly leukemogenic MLL fusion proteins have a unique mechanism of action. This review summarizes the current knowledge of how MLL fusions interact with the transcriptional machinery and it proposes a hypothesis how these proteins modify transcriptional control to act as transcriptional amplifiers causing runaway production of certain RNAs that transform hematopoietic cells.

中文翻译：

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MLL融合蛋白和转录控制。

高度致白血病的MLL融合蛋白具有独特的作用机制。这篇综述总结了有关MLL融合如何与转录机制相互作用的当前知识，并提出了一个假设，即这些蛋白质如何修饰转录控制以充当转录扩增子，从而导致某些转化造血细胞的RNA失控。