In amblyopia, there is an interocular suppressive imbalance that results in the fixing eye dominating perception. In this study, we aimed to determine whether these suppressive interactions were narrowband and tuned for spatial frequency or broadband and independent of spatial frequency. We measured the contrast sensitivity and masking functions of fifteen amblyopic subjects and seventeen control subjects using the quick Contrast Sensitivity Function (qCSF) approach (Lesmes, Lu, Baek, & Albright, 2010). We first measured the monocular sensitivity functions of each participant and thereafter corrected for it. We then measured masking sensitivity functions for low, mid and high spatial frequency masks, normalized to their visibility. In the control group, we observed that the strength of dichoptic masking is equivalent between the two eyes. It is also tuned such that masking by low spatial frequencies in one eye mainly affects low spatial frequencies in the other eye and masking by high spatial frequencies mainly affects high spatial frequencies. In amblyopes, although the interocular masking is also tuned for spatial frequency, it is not equivalent between the two eyes: the masking effect from the amblyopic to fixing eye is weaker than the other way around. The asymmetry observed in the strength of masking between the two eyes in amblyopia is tuned for spatial frequency. It is not the consequence of the contrast sensitivity deficit of the amblyopic eye nor is it the consequence of abnormally strong masking from the fixing eye. Rather it is due to an abnormally weak masking strength by the amblyopic eye per se.

中文翻译：

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弱视的眼内抑制性相互作用取决于空间频率。

在弱视中，存在眼内抑制性失衡，导致固定眼主导感知。在这项研究中，我们旨在确定这些抑制性相互作用是窄带的，还是针对空间频率或宽带进行了调谐，并且与空间频率无关。我们使用快速对比敏感度函数（qCSF）方法（Lesmes，Lu，Baek和Albright，2010年）测量了15名弱视受试者和17名对照受试者的对比敏感度和掩蔽功能。我们首先测量每个参与者的单眼敏感度函数，然后对其进行校正。然后，我们测量了低，中和高空间频率蒙版的蒙版灵敏度函数，并根据其可见性进行了标准化。在对照组中，我们观察到两只眼睛之间的两极掩蔽强度是等效的。还进行了调整，以使一只眼睛的低空间频率掩蔽主要影响另一只眼睛的低空间频率，而高空间频率的掩蔽则主要影响高空间频率。在弱视患者中，尽管也对眼内掩膜的空间频率进行了调整，但两只眼睛之间的掩盖效果并不相同：从弱视到固定眼的掩膜效果比其他方法弱。弱视中两只眼睛之间掩盖强度的不对称性针对空间频率进行了调整。这既不是弱视眼对比度敏感度不足的结果，也不是注视眼强力掩盖异常的结果。而是由于弱视本身的遮盖强度异常弱。