Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey (Callithrix jacchus).,American Journal of Primatology

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Maternal weight affects placental DNA methylation of genes involved in metabolic pathways in the common marmoset monkey (Callithrix jacchus).
American Journal of Primatology ( IF 2.0 ) Pub Date : 2020-02-05 , DOI: 10.1002/ajp.23101
Laren Narapareddy ₁ , Derek E Wildman ₂ , Don L Armstrong ₃ , Amy Weckle ₄ , Aleeca F Bell ₅ , Crystal L Patil ₅ , Suzette D Tardif ₆ , Corinna N Ross ₇ , Julienne N Rutherford ₅

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Accumulating evidence suggests that dysregulation of placental DNA methylation (DNAm) is a mechanism linking maternal weight during pregnancy to metabolic programming outcomes. The common marmoset, Callithrix jaccus, is a platyrrhine primate species that has provided much insight into studies of the primate placenta, maternal condition, and metabolic programming, yet the relationships between maternal weight and placental DNAm are unknown. Here, we report genome-wide DNAm from term marmoset placentas using reduced representation bisulfite sequencing. We identified 74 genes whose DNAm pattern is associated with maternal weight during gestation. These genes are predominantly involved in energy metabolism and homeostasis, including the regulation of glycolytic and lipid metabolic processes pathways.

中文翻译：

母体体重影响普通狨猴 (Callithrix jacchus) 代谢途径中涉及的基因的胎盘 DNA 甲基化。

越来越多的证据表明，胎盘 DNA 甲基化 (DNAm) 的失调是一种将孕期孕妇体重与代谢编程结果联系起来的机制。常见的狨猴 Callithrix jaccus 是一种扁嘴灵长类动物，它为灵长类动物胎盘、母体状况和代谢程序的研究提供了很多见解，但母体体重与胎盘 DNAm 之间的关系尚不清楚。在这里，我们使用减少代表性的亚硫酸氢盐测序报告了来自术语狨猴胎盘的全基因组 DNAm。我们鉴定了 74 个基因，其 DNAm 模式与妊娠期间的母体体重相关。这些基因主要参与能量代谢和体内平衡，包括糖酵解和脂质代谢过程途径的调节。

更新日期：2020-04-13

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