Proper fluid balance is critical for life. Learning plays an important role in shaping the appetitive behaviors required for drinking. Children often forego drinking plain water and instead consume beverages such as milk or juice. What effect this may have on adult thirst responses remains an open question. To model aspects of the human condition, we bred Sprague-Dawley rats and prevented the pups from obtaining fluid other than from nursing. Pups were weaned onto either tap water, 5% sucrose, or 0.45% saline, and given access to only that fluid for at least 7 weeks. We then measured intake of water or sucrose/saline in one-bottle tests after mild hypertonic saline (HS) injection, or overnight fluid deprivation, and in two-bottle tests after HS injection while rats were maintained on their respective fluids, and after all subjects had only water to drink for a week. We found that sucrose- and saline-maintained rats drank less water than did controls after the HS challenge. After overnight fluid deprivation, rats maintained on saline drank less water and more saline, but there was no difference in intake between water-maintained and sucrose-maintained rats. Differences in licking patterns, including more licks/burst for sucrose by sucrose-maintained rats were detected, even in cases when total intake was not different. These data provide evidence that adult rat water intake can be reduced by exclusively drinking sucrose or saline early in life.

中文翻译：

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在生命早期仅饮用蔗糖或盐水会改变实验室大鼠的成年饮酒行为

适当的体液平衡对生命至关重要。学习在塑造饮酒所需的食欲行为方面起着重要作用。孩子们经常放弃喝白开水，而是喝牛奶或果汁等饮料。这可能对成人口渴反应产生什么影响仍然是一个悬而未决的问题。为了模拟人类状况的各个方面，我们饲养了 Sprague-Dawley 大鼠并防止幼崽获得除哺乳以外的液体。幼崽被断奶到自来水、5% 蔗糖或 0.45% 生理盐水中，并且只能接触这种液体至少 7 周。然后，我们在轻度高渗盐水 (HS) 注射或隔夜液体剥夺后的一瓶测试中测量水或蔗糖/盐水的摄入量，并在注射 HS 后的两瓶测试中测量水或蔗糖/盐水的摄入量，同时大鼠保持各自的液体，毕竟，受试者一周只能喝水。我们发现用蔗糖和盐水维持的大鼠在 HS 挑战后喝的水比对照组少。隔夜液体剥夺后，维持在盐水上的大鼠喝了更少的水和更多的盐水，但保持水和保持蔗糖的大鼠之间的摄入量没有差异。即使在总摄入量没有不同的情况下，也检测到了舔食模式的差异，包括蔗糖维持大鼠的蔗糖舔食次数/爆发次数更多。这些数据提供的证据表明，成年大鼠在生命早期只喝蔗糖或盐水可以减少水的摄入量。维持生理盐水的大鼠喝了更少的水和更多的生理盐水，但维持水和蔗糖维持的大鼠之间的摄入量没有差异。即使在总摄入量没有不同的情况下，也检测到了舔食模式的差异，包括蔗糖维持大鼠的蔗糖舔食次数/爆发次数更多。这些数据提供的证据表明，成年大鼠在生命早期只喝蔗糖或盐水可以减少水的摄入量。维持生理盐水的大鼠喝了更少的水和更多的生理盐水，但维持水和蔗糖维持的大鼠之间的摄入量没有差异。即使在总摄入量没有不同的情况下，也检测到了舔食模式的差异，包括蔗糖维持大鼠的蔗糖舔食次数/爆发次数更多。这些数据提供的证据表明，成年大鼠在生命早期只喝蔗糖或盐水可以减少水的摄入量。