Consumption of added sugars in the US is estimated to be approximately 1.5 times recommended levels and has been linked to increased risk for developing chronic diseases. We hypothesized that relative to sugar, honey would reduce energy intake and improve serum lipid profiles. To test this, we assessed the short-term (1-week) and relatively long-term (1-month) effects of honey versus sucrose on changes in dietary intake and serum lipid concentrations. Thirty-seven apparently healthy subjects (21 males; 16 females) aged 24-57 years (BMI = 17.6-37.2 kg/m2) completed two 4-week trials in a randomized, cross-over design separated by ≥4-week washout. During each trial, subjects consumed either clover honey or sucrose providing 1.2 g/kg/day of carbohydrate under free-living conditions with instructions to avoid changing their habitual food intake. Serum triglyceride (TG) concentrations were elevated (P < .05) after 1 week for both trials but only remained elevated (P < .05) at the 4-week time-point during sucrose consumption. The elevation after 1 week during the honey trial was concurrent with a transient increase (P < .05) in body weight. No effects on serum concentrations of insulin, total cholesterol, low density lipoprotein-cholesterol, or high density lipoprotein-cholesterol were detected for either trial. Subjects consumed significantly less energy (P < .05), carbohydrate (P < .005), sugars (P < .05), and saturated fat (P < .05) during the honey trial. These data suggest that honey may serve as a favorable substitute for sucrose with regard to reduced energy intake, carbohydrate and sugars, without negatively influencing serum lipid concentrations.

中文翻译：

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蜂蜜不会对成年男性和女性的血脂产生不利影响：一项随机交叉试验

在美国，添加糖的消费量估计约为推荐水平的 1.5 倍，并且与患慢性病的风险增加有关。我们假设相对于糖，蜂蜜会减少能量摄入并改善血清脂质特征。为了测试这一点，我们评估了蜂蜜与蔗糖对饮食摄入和血清脂质浓度变化的短期（1 周）和相对长期（1 个月）的影响。37 名年龄在 24-57 岁（BMI = 17.6-37.2 kg/m2）的表面健康受试者（21 名男性；16 名女性）完成了两项为期 4 周的随机交叉设计试验，试验间隔≥4 周。在每次试验期间，受试者在自由生活条件下食用三叶草蜂蜜或蔗糖，提供 1.2 g/kg/天的碳水化合物，并附有避免改变其习惯性食物摄入量的说明。两项试验的血清甘油三酯 (TG) 浓度在 1 周后升高（P < .05），但仅在蔗糖消耗期间的 4 周时间点保持升高（P < .05）。蜂蜜试验期间 1 周后的升高与体重的短暂增加 (P < .05) 同时发生。两项试验均未检测到对胰岛素、总胆固醇、低密度脂蛋白-胆固醇或高密度脂蛋白-胆固醇的血清浓度产生影响。在蜂蜜试验期间，受试者消耗的能量 (P < .05)、碳水化合物 (P < .005)、糖 (P < .05) 和饱和脂肪 (P < .05) 显着减少。这些数据表明，在减少能量摄入、碳水化合物和糖分方面，蜂蜜可以作为蔗糖的有利替代品，而不会对血清脂质浓度产生负面影响。