Metabolic and weight phenotype-specific relationships between high-sensitivity C-reactive protein (hsCRP) and handgrip strength (HGS) may compare the phenotypes that can potentially influence association between HGS and hsCRP risk. However, these phenotype-related differences remain unclear. The present study investigated the associations between HGS assessed using raw HGS of each hand and relative HGS (HGS/body mass index [BMI]) and hsCRP status according to metabolic and weight phenotypes. In 15 061 Korean adults (50.8 ± 16.6 years) with complete data from the Korea National Health and Nutrition Examination Survey from 2015 to 2017, hsCRP levels were classified into high risk (>3 mg/L) vs low to average risk. Metabolic and weight phenotypes were categorized into 6 groups according to the number of metabolic syndrome (MetS) components (0/1-2/3-4) and the absence/presence of obesity (BMI ≥ 25 kg/m2). After adjusting for confounding factors (demographics, treatment of concurrent illnesses, and health-related behaviors), high-risk hsCRP had inverse associations with HGS values, whereas it had positive associations with phenotypes having higher number of MetS components and higher BMI in both sexes. In both men and women, increases of all HGS were not associated with high-risk hsCRP in the nonobese phenotype without MetS components after adjusting for confounding factors. However, those increases in HGS had inverse associations with high-risk hsCRP in either men or women with at least 1 MetS component, regardless of coexistent weight status, and those with obesity, regardless of coexistent MetS components. In conclusion, strong HGS may be more favorable for individuals with high-risk hsCRP when they have obesity or metabolically unhealthy phenotypes.

中文翻译：

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代谢综合征和体重状态可能会改变韩国成年人握力与 C 反应蛋白之间的负相关

高敏 C 反应蛋白 (hsCRP) 和握力 (HGS) 之间的代谢和体重表型特异性关系可以比较可能影响 HGS 和 hsCRP 风险之​​间关联的表型。然而，这些与表型相关的差异仍不清楚。本研究根据代谢和体重表型调查了使用每只手的原始 HGS 评估的 HGS 与相对 HGS（HGS/体重指数 [BMI]）和 hsCRP 状态之间的关联。在 2015 年至 2017 年韩国国家健康和营养检查调查中拥有完整数据的 15 061 名韩国成年人（50.8 ± 16.6 岁）中，hsCRP 水平被分为高风险（> 3 mg/L）和低至平均风险。根据代谢综合征 (MetS) 成分的数量 (0/1-2/3-4) 和不存在/存在肥胖 (BMI ≥ 25 kg/m2)，将代谢和体重表型分为 6 组。在调整混杂因素（人口统计学、并发疾病的治疗和健康相关行为）后，高危 hsCRP 与 HGS 值呈负相关，而它与两性中 MetS 成分数量较多和 BMI 较高的表型呈正相关. 在男性和女性中，在调整混杂因素后，所有 HGS 的增加与不含 MetS 成分的非肥胖表型中的高风险 hsCRP 无关。然而，无论是否同时存在体重状况，HGS 的增加与至少有 1 个 MetS 成分的男性或女性的高风险 hsCRP 呈负相关，和肥胖者，无论是否存在 MetS 成分。总之，当高危 hsCRP 个体有肥胖或代谢不健康表型时，强 HGS 可能更有利。