BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease. Although pulmonary function test (PFT) is useful for evaluating the progression of IPF, obtaining adequate results in advanced cases can be challenging. Conversely, the forced oscillation technique (FOT) can be noninvasively performed, even in patients with severely deteriorated lung function. In this study, the usefulness of FOT for the evaluation of IPF disease status was investigated. METHODS We analyzed the PFT and FOT data of 97 patients with IPF. RESULTS The respiratory reactance (Xrs) components of FOT, especially in the inspiratory phase, correlated with the PFT values. Patients with advanced disease had significantly lower reactance at 5 Hz (X5), higher resonant frequency (Fres) and low-frequency reactance area (ALX). The longitudinal deterioration of Xrs was also observed. Moreover, X5 in the inspiratory phase predicted subsequent lung capacity deterioration. CONCLUSION The Xrs components of FOT, especially in the inspiratory phase, reflected restrictive ventilatory impairment and disease severity in patients with IPF.

中文翻译：

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强迫振荡技术中的呼吸反应反映疾病阶段，并预测特发性肺纤维化中肺生理的恶化。

背景技术特发性肺纤维化（IPF）是一种慢性进行性疾病。尽管肺功能测试（PFT）可用于评估IPF的进展，但在晚期病例中获得足够的结果可能是具有挑战性的。相反，即使在肺功能严重恶化的患者中，也可以无创地执行强制振荡技术（FOT）。在这项研究中，调查了FOT在评估IPF疾病状态方面的有用性。方法我们分析了97例IPF患者的PFT和FOT数据。结果FOT的呼吸电抗（Xrs）成分，特别是在吸气阶段，与PFT值相关。患有晚期疾病的患者在5 Hz（X5）时的电抗明显较低，共振频率（Fres）较高，而低频电抗面积（ALX）。还观察到Xrs的纵向劣化。此外，吸气阶段的X5预测随后的肺活量会下降。结论FOT的Xrs成分，特别是在吸气阶段，反映了IPF患者的限制性通气障碍和疾病严重程度。