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The Promise of CRISPR for Human Germline Editing and the Perils of "Playing God".
The CRISPR Journal ( IF 3.7 ) Pub Date : 2020-02-01 , DOI: 10.1089/crispr.2019.0033
Larry G Locke 1
Affiliation  

In the midst of the media and professional exuberance regarding the potential benefits of CRISPR technology, voices of criticism and caution have also arisen. One of the thorniest such cautions has been the common objection that CRISPR allows bioscientists to "play God," particularly when it comes to potentially editing the human germline. Many in the biotechnology field are unsure how to address this concern. What does it mean, particularly for bioscientists who may not have any rational or rhetorical categories for God? In this article, I explore possible meanings of "playing God" and the arguments for how those meanings might be applied in the utilization of CRISPR technology for human germline editing. I then test the validity of those arguments and explore potential counterarguments. Finally, I discuss how members of the bioscience community might respond to the objection of "playing God" and contribute to that dialogue in ways that could impact the future of CRISPR development and applications.

中文翻译:

CRISPR对人类种系编辑的承诺以及“扮演上帝”的危险。

在媒体和专业人士对CRISPR技术的潜在好处的热烈欢迎中,也出现了批评和谨慎的声音。最为棘手的此类警告之一就是人们普遍反对CRISPR允许生物科学家“扮演上帝”,特别是在潜在地编辑人类种系的过程中。生物技术领域的许多人不确定如何解决这个问题。这是什么意思,特别是对于可能对上帝没有任何理性或修辞范畴的生物科学家而言?在本文中,我探讨了“扮演上帝”的可能含义,以及在将CRISPR技术用于人类种系编辑中如何应用这些含义的争论。然后,我测试这些论点的有效性并探讨潜在的反论点。最后,
更新日期:2020-02-01
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