There is a lack of information correlating low adiposity with hypertension experienced by Spontaneous Hypertensive Rats (SHR) or overweight and normotension in Wistar-Kyoto (WKY). We aimed to investigate this lipodystrophy phenomenon by measuring fluorescence lifetime (FLIM), optical redox ratio (ORR), serum levels of hypothalamic-pituitary-adrenal (HPA) and/or hypothalamic-pituitary-thyroid (HPT) hormones axes between Wistar, WKY and SHR before and after establishment of hypertension. Under high blood pressure, we evaluated serum adipokines. Brown adipose tissue was characterized as lower ORR and shorter FLIM compared to white adipose tissue. HPT axis showed a crucial role in the SHR adipose tissue configuration by attenuating whitening. The increased adiposity in WKY may act as a preventive agent for hypertension, since SHR, with low adiposity, establishes the disease. The hypertensive environment can highlight key adipokines that may result in new therapeutic approaches to the treatment of adiposity dysfunctions and hypertension.

中文翻译：

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高血压环境对自发性高血压大鼠的荧光寿命成像测量的脂肪组织重塑的影响。

缺乏与自发性高血压大鼠（SHR）经历的高血压或高血压，Wistar-Kyoto（WKY）超重和正常血压相关的信息。我们旨在通过测量Wistar，WKY之间的荧光寿命（FLIM），光学氧化还原比（ORR），下丘脑-垂体-肾上腺（HPA）和/或下丘脑-垂体-甲状腺（HPT）激素水平来研究这种脂肪营养不良现象。和SHR在高血压建立前后。在高血压下，我们评估了血清脂肪因子。与白色脂肪组织相比，棕色脂肪组织的特征是ORR较低且FLIM较短。HPT轴通过减弱美白作用，在SHR脂肪组织结构中显示出至关重要的作用。WKY中肥胖的增加可能是高血压的预防剂，因为SHR的肥胖程度很低，建立疾病。高血压环境可能会突出关键的脂肪因子，从而可能导致治疗肥胖症和高血压的新治疗方法。