Allogeneic hematopoietic cell transplantation (alloHCT) is a life-saving technology that can cure otherwise incurable diseases, but imposes significant physiologic stress upon recipients. This stress leads to short-term toxicity and mid- to long-term physical function impairment in some recipients. Exercise interventions have demonstrated preliminary efficacy in preserving physical function in HCT recipients, but the role of these interventions prior to HCT (prehabilitative) is less known. We tested a 5- to 12-week, prehabilitative higher intensity home-based aerobic exercise intervention in a randomized study of alloHCT candidates. Of 113 patients screened, 34 were randomized to control or intervention groups, 16 underwent pre- and post-intervention peak oxygen consumption (VO2peak) testing, and 12 underwent pre- and post-intervention 6-min walk distance (6MWD) testing. No significant differences in VO2peak or 6MWD were seen pre- to post-intervention between intervention and control groups, but final numbers of evaluable participants in each group were too small to draw inferences regarding the efficacy of the intervention. We conclude that the design of our prehabilitative intervention was not feasible in this pilot randomized study, and make recommendations regarding the design of future exercise intervention studies in alloHCT.

中文翻译：

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从同种异体造血细胞移植前家庭运动处方试点随机临床试验中吸取的经验教训。


异基因造血细胞移植（alloHCT）是一种挽救生命的技术，可以治愈其他无法治愈的疾病，但会给受者带来巨大的生理压力。这种压力会导致一些接受者出现短期毒性和中长期身体功能损伤。运动干预已显示出在保持 HCT 接受者身体功能方面的初步功效，但这些干预措施在 HCT（康复）之前的作用鲜为人知。我们在一项针对 alloHCT 候选者的随机研究中测试了为期 5 至 12 周的康复前高强度家庭有氧运动干预。在筛选的 113 名患者中，34 名被随机分为对照组或干预组，16 名患者接受干预前后峰值耗氧量 (VO2peak) 测试，12 名患者接受干预前后 6 分钟步行距离 (6MWD) 测试。干预组和对照组之间在干预前后的 VO2peak 或 6MWD 没有显着差异，但每组中可评估的参与者的最终人数太少，无法推断干预的效果。我们的结论是，我们的预康复干预设计在这项试点随机研究中是不可行的，并就 alloHCT 中未来运动干预研究的设计提出了建议。