Evidence suggests that pediatric traumatic brain injury (TBI) may be causally related to alcohol misuse later in life; however, the nature and extent of the association has not been well described. This study examined the relationship between pediatric TBI and adult alcohol misuse in a population sample ≥20 years of age. We sought to determine (1) whether first self-reported incidence of TBI with loss of consciousness (LOC) before the age of 20 increased the risk for alcohol misuse later in life; and (2) whether sex, injury severity, and age at time of injury modified the association. We found a greater likelihood of binge but not heavy drinking for those whose first self-reported TBI with LOC occurred before the age of 20 when compared with those whose first self-reported TBI with LOC occurred later in life (28.5% vs. 20.4%, p = 0.003). When limited to those with only mild TBI, the relationship to binge drinking remained significant (31.9% vs. 19.3%, p < 0.001) and was evident for both males (38.4% vs. 25.6%, p = 0.016) and females (20.9% vs. 12.4%, p = 0.044). When controlling for sex, age, and race/ethnicity, reporting a first TBI with LOC before age 20 was associated with binge drinking only for those with mild TBI (adjusted odds ratio [AOR] = 1.32; 95% confidence interval [CI] = 1.00–1.74). Results also showed that those with first TBI with LOC occurring between the ages of 10 and 19 years were more likely to binge drink as adults than those first injured earlier in life, regardless of TBI severity. Further research is needed at both the epidemiological and pre-clinical levels to better understand this relationship.

中文翻译：

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小儿创伤性脑损伤与成人酒精滥用有关吗？

有证据表明，儿科创伤性脑损伤 (TBI) 可能与晚年酗酒有因果关系；然而，这种关联的性质和范围没有得到很好的描述。本研究在 20 岁以上的人群样本中检查了儿科 TBI 与成人酒精滥用之间的关系。我们试图确定 (1) 在 20 岁之前首次自我报告的伴有意识丧失 (LOC) 的 TBI 发病率是否会增加以后生活中滥用酒精的风险；(2) 性别、损伤严重程度和受伤时的年龄是否改变了这种关联。我们发现，与第一次自我报告的 TBI 与 LOC 发生在晚年的那些人相比，那些第一次自我报告的 TBI 与 LOC 发生在 20 岁之前的人更可能暴饮暴食（28.5% 对 20.4%） ,p  = 0.003）。当仅限于轻度 TBI 患者时，与酗酒的关系仍然显着（31.9% 对 19.3%，p  < 0.001），并且对男性（38.4% 对 25.6%，p  = 0.016）和女性（20.9 ）都很明显% 与 12.4%，p = 0.044）。当控制性别、年龄和种族/民族时，报告在 20 岁之前首次发生 LOC 的 TBI 仅与轻度 TBI 患者的酗酒有关（调整后的优势比 [AOR] = 1.32；95% 置信区间 [CI] = 1.00–1.74）。结果还表明，无论 TBI 的严重程度如何，与那些在生命早期首次受伤的人相比，那些在 10 至 19 岁之间发生 LOC 的首次 TBI 的人更可能在成年后酗酒。需要在流行病学和临床前水平进行进一步研究，以更好地了解这种关系。