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Neonatal exposure to bisphenol A advances pubertal development in female rats.
Molecular Reproduction and Development ( IF 2.7 ) Pub Date : 2020-02-28 , DOI: 10.1002/mrd.23329 Jing Qiu 1 , Yanyan Sun 1 , Wen Sun 1 , Yonghong Wang 1 , Teng Fan 1 , Jian Yu 1
Molecular Reproduction and Development ( IF 2.7 ) Pub Date : 2020-02-28 , DOI: 10.1002/mrd.23329 Jing Qiu 1 , Yanyan Sun 1 , Wen Sun 1 , Yonghong Wang 1 , Teng Fan 1 , Jian Yu 1
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Neonatal exposure to bisphenol A (BPA) is hypothesized to advance pubertal development. However, the effects of neonatal BPA exposure on pubertal development has not been described. In this study, female Sprague-Dawley rats were exposed to 0.05, 0.5, 5, or 10 mg·kg-1 ·day-1 BPA, or corn oil vehicle alone from postnatal day 1 (PND1) to PND10 via subcutaneous injection. We evaluated day of vaginal opening (DVO), ovarian morphology, serum hormone concentrations, and hypothalamic expression of Gnrh1 and Kiss1 in female rats at PND35. DVO was significantly advanced in rats exposed to 5 and 10 mg·kg-1 ·day-1 BPA. Serum hormone concentrations increased as BPA dose increased. Additionally, hypothalamic Gnrh1 and Kiss1 expression were increased with BPA exposure; rats exposed to 10 mg·kg-1 ·day-1 BPA had significantly upregulated hypothalamic Gnrh1 and Kiss1 expressions in terms of both messenger RNA and protein levels. Our results suggest that exposure to a 10 mg·kg-1 ·day-1 dose of BPA might advance pubertal development significantly. In addition, within the range of 0 to 10 mg·kg-1 ·day-1 , neonatal exposure to BPA may affect pubertal development in a dose-dependent manner.
中文翻译：
新生儿双酚A暴露会使雌性大鼠青春期发育。
新生儿可能接触双酚A（BPA）以促进青春期发育。但是，尚未描述新生儿BPA暴露对青春期发育的影响。在这项研究中，雌性Sprague-Dawley大鼠从出生后第1天（PND1）到PND10，仅通过皮下注射就暴露于0.05、0.5、5或10 mg·kg-1·day-1 BPA或玉米油载体。我们在PND35评估雌性大鼠的阴道开放日（DVO），卵巢形态，血清激素浓度以及下丘脑Gnrh1和Kiss1表达。DVO在暴露于5和10 mg·kg-1·day-1 BPA的大鼠中显着进展。血清激素浓度随BPA剂量的增加而增加。此外，BPA暴露下丘脑Gnrh1和Kiss1表达增加。暴露于10 mg·kg-1·day-1 BPA的大鼠在信使RNA和蛋白质水平方面均明显下丘脑Gnrh1和Kiss1表达上调。我们的结果表明，暴露于10 mg·kg-1·day-1剂量的BPA可能会显着促进青春期发育。此外，在0至10 mg·kg-1·day-1的范围内，新生儿接触BPA可能以剂量依赖的方式影响青春期的发育。
更新日期：2020-02-28
中文翻译：
新生儿双酚A暴露会使雌性大鼠青春期发育。
新生儿可能接触双酚A（BPA）以促进青春期发育。但是，尚未描述新生儿BPA暴露对青春期发育的影响。在这项研究中，雌性Sprague-Dawley大鼠从出生后第1天（PND1）到PND10，仅通过皮下注射就暴露于0.05、0.5、5或10 mg·kg-1·day-1 BPA或玉米油载体。我们在PND35评估雌性大鼠的阴道开放日（DVO），卵巢形态，血清激素浓度以及下丘脑Gnrh1和Kiss1表达。DVO在暴露于5和10 mg·kg-1·day-1 BPA的大鼠中显着进展。血清激素浓度随BPA剂量的增加而增加。此外，BPA暴露下丘脑Gnrh1和Kiss1表达增加。暴露于10 mg·kg-1·day-1 BPA的大鼠在信使RNA和蛋白质水平方面均明显下丘脑Gnrh1和Kiss1表达上调。我们的结果表明，暴露于10 mg·kg-1·day-1剂量的BPA可能会显着促进青春期发育。此外，在0至10 mg·kg-1·day-1的范围内，新生儿接触BPA可能以剂量依赖的方式影响青春期的发育。
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