Delayed onset muscle soreness (DOMS) is a multifactorial progression related to muscle pain, swelling, stiffness, tenderness, altered joint kinematics, muscle fiber disruption, decreased strength and power, and acute tissue damage. Curcumin, a natural phytonutrient, could manage DOMS induced by eccentric continuous exercise due to its wide range of biological activities. This study was a randomized, placebo-controlled, double-blind clinical study to assess the efficacy of Cureit™—a bioavailable form of curcumin that may decrease damage from inflammation and oxidative stress associated with severe muscle damage induced by continuous eccentric exercise. The results of the study showed that oral consumption of Cureit significantly reduced DOMS, slightly reduced creatinine kinase concentrations, and slightly increased VO₂ max value compared with placebo, and found safe for administration. The consumption of Cureit led to improved recovery and reduction of DOMS without any side effects due to the enhancement of bioavailable form of curcumin.

中文翻译：

---

生物利用姜黄素（Cureit）对偏心连续运动引起的迟发性肌肉酸痛的影响：一项随机，安慰剂对照，双盲临床研究。

迟发性肌肉酸痛（DOMS）是与肌肉疼痛，肿胀，僵硬，压痛，关节运动学改变，肌肉纤维破裂，力量和力量下降以及急性组织损伤有关的多因素进展。姜黄素是一种天然的植物营养素，由于其广泛的生物活性，因此可以控制由于连续不断的离心运动而引起的DOMS。这项研究是一项随机，安慰剂对照，双盲临床研究，旨在评估Cureit™的功效。Cureit™是姜黄素的一种生物利用形式，可减少炎症和氧化应激所致的伤害，而炎症和氧化应激与持续离心运动引起的严重肌肉损伤有关。研究结果表明，口服Cureit可以显着降低DOMS，稍微降低肌酸酐激酶浓度和稍微增加VO _2。与安慰剂相比有最大价值，并且可以安全使用。由于姜黄素的生物利用度的提高，Cureit的使用可提高DOMS的回收率并减少其副作用，而无任何副作用。