This article provides comprehensive and collective facts about teneligliptin. Teneligliptin is a dipeptide peptidase-4 (DPP-4) inhibitor that belongs to the third generation, used in the management of type 2 diabetes. It inhibits human DPP-4 enzyme activity. This drug falls under class 3; it interacts with S1, S2, and S2E extensive sub-sites. Teneligliptin and its metabolites are mainly determined in the human plasma matrix by hyphenated chromatographic methods. These developed methods could be foreseen for their clinical applications. Moreover, the stress degradation studies of Teneligliptin under different stress conditions provide an insight into degradation pathways and help in the elucidation of the structure of the degradation products by liquid mass spectroscopy. These methods are also used for routine quality control analysis of teneligliptin in pharmaceutical dosage forms.

本文提供有关Teneligliptin的全面和集体的事实。特立格列汀是属于第三代的二肽肽酶-4（DPP-4）抑制剂，用于治疗2型糖尿病。它抑制人DPP-4酶的活性。该药物属于第3类；它与S1，S2和S2E广泛的子站点进行交互。特立格列汀及其代谢产物主要通过连接色谱法在人血浆基质中测定。这些发达的方法可以预见其临床应用。此外，替尼利普汀在不同应力条件下的应力降解研究提供了降解途径的见解，并有助于通过液相质谱法阐明降解产物的结构。