The development of adequate experimental models is crucial to furthering the current mechanistic understanding of the etiopathogenesis, subsequent growth, and ultimate metastasis of breast cancer, to develop targeted diagnostics and therapeutics such as the identification of new treatments for multidrug-resistant tumors and triple-negative breast cancers. The utility of new therapeutic options is limited by the platforms currently used to test their efficacy in vitro. The use of three-dimensional models, which incorporate patient-specific, primary cells, offers significant advantages over traditional two-dimensional models by providing a means of accurately recapitulating the complex tumor microenvironment. Advances in breast cancer models, in turn, stand to contribute to more efficacious breast cancer therapeutics. Herein, we review the recent advances in experimental models of breast cancer and suggest methods by which these can be used to further our understanding of said cancer.

中文翻译：

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用于研究乳腺肿瘤疾病和肿瘤微环境的组织工程模型。

开发适当的实验模型对于进一步深入了解乳腺癌的发病机制、随后的生长和最终转移的机制，开发靶向诊断和治疗方法，例如确定针对多药耐药肿瘤和三阴性肿瘤的新治疗方法至关重要。乳腺癌。新治疗方案的效用受到目前用于在体外测试其功效的平台的限制. 使用包含患者特异性原代细胞的三维模型，通过提供一种准确概括复杂肿瘤微环境的手段，提供了优于传统二维模型的显着优势。反过来，乳腺癌模型的进步有助于更有效的乳腺癌治疗。在此，我们回顾了乳腺癌实验模型的最新进展，并提出了可用于进一步了解所述癌症的方法。