Chemerin is a multifunctional protein involved among others in adipogenesis, angiogenesis and lipid as well as glucose metabolism. Chemerin is an essential factor in promotion of chemotaxis of numerous immune cell types and plays an important role in several pathophysiologic conditions. Chemerin receptors are present on monocytes/macrophages, T cells, natural killer and dendritic cells as well as neutrophils. However, the role of chemerin and chemerin receptors in immune response and gastrointestinal diseases is still poorly understood. Accumulating, clinical and experimental studies observed disturbation of chemerin and chemerin receptors in a number of disorders including Barrett's esophagus, esophageal cancer, gastric cancer, hepatic dysfunction, irritable bowel syndrome, inflammatory bowel disease and colorectal cancer. Moreover, chemerin and chemerin receptors have been shown to regulate proliferation, migration and invasion of gastrointestinal and immune cells as well as cancer-associated fibroblasts. In this review we present the current state of knowledge about the contribution of chemerin to immune response and gastrointestinal disorders.

中文翻译：

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Chemerin 在免疫反应和胃肠道病理生理学中的作用。

Chemerin 是一种多功能蛋白质，其中涉及脂肪生成、血管生成和脂质以及葡萄糖代谢。Chemerin 是促进多种免疫细胞类型趋化性的重要因素，并在多种病理生理条件下发挥重要作用。Chemerin 受体存在于单核细胞/巨噬细胞、T 细胞、自然杀伤细胞和树突细胞以及中性粒细胞上。然而，chemerin 和chemerin 受体在免疫反应和胃肠道疾病中的作用仍然知之甚少。越来越多的临床和实验研究观察到 chemerin 和 chemerin 受体在许多疾病中受到干扰，包括 Barrett 食管、食管癌、胃癌、肝功能障碍、肠易激综合征、炎症性肠病和结肠直肠癌。而且，chemerin 和 chemerin 受体已被证明可以调节胃肠道和免疫细胞以及癌症相关成纤维细胞的增殖、迁移和侵袭。在这篇综述中，我们介绍了关于凯莫瑞对免疫反应和胃肠道疾病的贡献的当前知识状态。