Abstract

New bioactive 13-epi-neoverrucosane diterpenoid, 5β-acetoxy-13-epi-neoverrucosanic acid (1) along with three known secondary metabolites, 13-epi-neoverrucosan-5β-ol (2), chelodane (3) and (E)-β-farnesene (4) were isolated from the MeOH extract of east Malaysia’s liverwort Pleurozia subinflata. The chemical structure of new compound was elucidated by the analyses of its spectroscopic data (FTIR, NMR and HR-ESI-MS). These epi-neoverrucosane-type compounds seem to be notable chemosystematic markers for P. subinflata in Borneo. Compound 3 was widespread in marine sponges however this is the first record for 3 to be found in liverwort. These metabolites were tested for their antifungal potentials against selected fungi from the marine environment. Compound 1 exhibited effective antifungal activity against Lagenidium thermophilum.

Graphic Abstract

中文翻译：

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来自婆罗洲Liverwort Pleurozia subinflata的一种新的上皮-过-二十二烷型双萜。

摘要

新的生物活性13-外延-neoverrucosane二萜类化合物，5β乙酰氧基-13-外延-neoverrucosanic酸（1具有三个已知次级代谢产物一起），13-外延-neoverrucosan-5β醇（2），chelodane（3）和（Ë） -β-法尼烯（4）是从东马来西亚黑麦地平菇菌丝体的甲醇提取物中分离得到的。通过分析其光谱数据（FTIR，NMR和HR-ESI-MS）阐明了该新化合物的化学结构。这些外延-neoverrucosane型化合物似乎是显着chemosystematic标记P. subinflata婆罗洲。化合物3在海生海绵中广泛存在，但这是在艾草中首次发现3的记录。测试了这些代谢物对海洋环境中选定真菌的抗真菌潜力。化合物1对热革霉表现出有效的抗真菌活性。

图形摘要