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A New Epi-neoverrucosane-type Diterpenoid from the Liverwort Pleurozia subinflata in Borneo.
Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2020-02-15 , DOI: 10.1007/s13659-020-00232-6 Takashi Kamada 1, 2 , Mary Lyn Johanis 2 , Shean-Yeaw Ng 2 , Chin-Soon Phan 2 , Monica Suleiman 2 , Charles S Vairappan 2
中文翻译:
来自婆罗洲Liverwort Pleurozia subinflata的一种新的上皮-过-二十二烷型双萜。
更新日期:2020-02-15
Natural Products and Bioprospecting ( IF 4.8 ) Pub Date : 2020-02-15 , DOI: 10.1007/s13659-020-00232-6 Takashi Kamada 1, 2 , Mary Lyn Johanis 2 , Shean-Yeaw Ng 2 , Chin-Soon Phan 2 , Monica Suleiman 2 , Charles S Vairappan 2
Affiliation
Abstract
New bioactive 13-epi-neoverrucosane diterpenoid, 5β-acetoxy-13-epi-neoverrucosanic acid (1) along with three known secondary metabolites, 13-epi-neoverrucosan-5β-ol (2), chelodane (3) and (E)-β-farnesene (4) were isolated from the MeOH extract of east Malaysia’s liverwort Pleurozia subinflata. The chemical structure of new compound was elucidated by the analyses of its spectroscopic data (FTIR, NMR and HR-ESI-MS). These epi-neoverrucosane-type compounds seem to be notable chemosystematic markers for P. subinflata in Borneo. Compound 3 was widespread in marine sponges however this is the first record for 3 to be found in liverwort. These metabolites were tested for their antifungal potentials against selected fungi from the marine environment. Compound 1 exhibited effective antifungal activity against Lagenidium thermophilum.Graphic Abstract
中文翻译:
来自婆罗洲Liverwort Pleurozia subinflata的一种新的上皮-过-二十二烷型双萜。